Decreased spermatogonial numbers in boys with severe haematological diseases

Atte K. Lahtinen; Miriam Funke; Claudia Krallmann; Margot J. Wyrwoll; Andrea Jarisch; Yifan Yang; Ragnar Bjarnason; Patrik Romerius; Mikael Sundin; Ulrika Norén-Nyström; Cecilia Langenskiöld; Jann Frederik Cremers; Sabine Kliesch; Jan Bernd Stukenborg; Nina Neuhaus; Kirsi Jahnukainen

doi:10.1111/bjh.19572

Decreased spermatogonial numbers in boys with severe haematological diseases

Atte K. Lahtinen^*, Miriam Funke, Claudia Krallmann, Margot J. Wyrwoll, Andrea Jarisch, Yifan Yang, Ragnar Bjarnason, Patrik Romerius, Mikael Sundin, Ulrika Norén-Nyström, Cecilia Langenskiöld, Jann Frederik Cremers, Sabine Kliesch, Jan Bernd Stukenborg, Nina Neuhaus, Kirsi Jahnukainen^*

^*Corresponding author for this work

Faculty of Medicine

Research output: Contribution to journal › Article › peer-review

Abstract

This study examines spermatogonial numbers in testicular samples from 43 prepubertal patients undergoing haematopoietic stem cell transplantation (HSCT). High-dose chemotherapy and/or radiation during HSCT can impact spermatogenesis requiring fertility preservation. Results show that 49% of patients have decreased and 19% severely depleted spermatogonial pool prior to HSCT. Patients with Fanconi anaemia exhibit significantly reduced spermatogonial numbers. Patients with immunodeficiency or aplastic anaemia generally present within the normal range, while results in patients with myelodysplastic syndrome or myeloproliferative neoplasm vary. The study emphasizes the importance of assessing spermatogonial numbers in patients with severe haematological diseases for informed fertility preservation decisions.

Original language	English
Pages (from-to)	229-235
Number of pages	7
Journal	British Journal of Haematology
Volume	205
Issue number	1
DOIs	https://doi.org/10.1111/bjh.19572
Publication status	Published - Jul 2024

Bibliographical note

Publisher Copyright:
© 2024 The Author(s). British Journal of Haematology published by British Society for Haematology and John Wiley & Sons Ltd.

Other keywords

bone marrow failure
fertility
immunodeficiency
MDS
myeloproliferative disease
stem cell transplantation

Access to Document

10.1111/bjh.19572

Cite this

Lahtinen, A. K., Funke, M., Krallmann, C., Wyrwoll, M. J., Jarisch, A., Yang, Y., Bjarnason, R., Romerius, P., Sundin, M., Norén-Nyström, U., Langenskiöld, C., Cremers, J. F., Kliesch, S., Stukenborg, J. B., Neuhaus, N., & Jahnukainen, K. (2024). Decreased spermatogonial numbers in boys with severe haematological diseases. British Journal of Haematology, 205(1), 229-235. https://doi.org/10.1111/bjh.19572

@article{b59c5e76165440bebd69036edf7e9ffa,

title = "Decreased spermatogonial numbers in boys with severe haematological diseases",

abstract = "This study examines spermatogonial numbers in testicular samples from 43 prepubertal patients undergoing haematopoietic stem cell transplantation (HSCT). High-dose chemotherapy and/or radiation during HSCT can impact spermatogenesis requiring fertility preservation. Results show that 49% of patients have decreased and 19% severely depleted spermatogonial pool prior to HSCT. Patients with Fanconi anaemia exhibit significantly reduced spermatogonial numbers. Patients with immunodeficiency or aplastic anaemia generally present within the normal range, while results in patients with myelodysplastic syndrome or myeloproliferative neoplasm vary. The study emphasizes the importance of assessing spermatogonial numbers in patients with severe haematological diseases for informed fertility preservation decisions.",

keywords = "bone marrow failure, fertility, immunodeficiency, MDS, myeloproliferative disease, stem cell transplantation",

author = "Lahtinen, {Atte K.} and Miriam Funke and Claudia Krallmann and Wyrwoll, {Margot J.} and Andrea Jarisch and Yifan Yang and Ragnar Bjarnason and Patrik Romerius and Mikael Sundin and Ulrika Nor{\'e}n-Nystr{\"o}m and Cecilia Langenski{\"o}ld and Cremers, {Jann Frederik} and Sabine Kliesch and Stukenborg, {Jan Bernd} and Nina Neuhaus and Kirsi Jahnukainen",

note = "Publisher Copyright: {\textcopyright} 2024 The Author(s). British Journal of Haematology published by British Society for Haematology and John Wiley & Sons Ltd.",

year = "2024",

month = jul,

doi = "10.1111/bjh.19572",

language = "English",

volume = "205",

pages = "229--235",

journal = "British Journal of Haematology",

issn = "0007-1048",

publisher = "Wiley-Blackwell Publishing Ltd",

number = "1",

}

Lahtinen, AK, Funke, M, Krallmann, C, Wyrwoll, MJ, Jarisch, A, Yang, Y, Bjarnason, R, Romerius, P, Sundin, M, Norén-Nyström, U, Langenskiöld, C, Cremers, JF, Kliesch, S, Stukenborg, JB, Neuhaus, N & Jahnukainen, K 2024, 'Decreased spermatogonial numbers in boys with severe haematological diseases', British Journal of Haematology, vol. 205, no. 1, pp. 229-235. https://doi.org/10.1111/bjh.19572

TY - JOUR

T1 - Decreased spermatogonial numbers in boys with severe haematological diseases

AU - Lahtinen, Atte K.

AU - Funke, Miriam

AU - Krallmann, Claudia

AU - Wyrwoll, Margot J.

AU - Jarisch, Andrea

AU - Yang, Yifan

AU - Bjarnason, Ragnar

AU - Romerius, Patrik

AU - Sundin, Mikael

AU - Norén-Nyström, Ulrika

AU - Langenskiöld, Cecilia

AU - Cremers, Jann Frederik

AU - Kliesch, Sabine

AU - Stukenborg, Jan Bernd

AU - Neuhaus, Nina

AU - Jahnukainen, Kirsi

PY - 2024/7

Y1 - 2024/7

N2 - This study examines spermatogonial numbers in testicular samples from 43 prepubertal patients undergoing haematopoietic stem cell transplantation (HSCT). High-dose chemotherapy and/or radiation during HSCT can impact spermatogenesis requiring fertility preservation. Results show that 49% of patients have decreased and 19% severely depleted spermatogonial pool prior to HSCT. Patients with Fanconi anaemia exhibit significantly reduced spermatogonial numbers. Patients with immunodeficiency or aplastic anaemia generally present within the normal range, while results in patients with myelodysplastic syndrome or myeloproliferative neoplasm vary. The study emphasizes the importance of assessing spermatogonial numbers in patients with severe haematological diseases for informed fertility preservation decisions.

AB - This study examines spermatogonial numbers in testicular samples from 43 prepubertal patients undergoing haematopoietic stem cell transplantation (HSCT). High-dose chemotherapy and/or radiation during HSCT can impact spermatogenesis requiring fertility preservation. Results show that 49% of patients have decreased and 19% severely depleted spermatogonial pool prior to HSCT. Patients with Fanconi anaemia exhibit significantly reduced spermatogonial numbers. Patients with immunodeficiency or aplastic anaemia generally present within the normal range, while results in patients with myelodysplastic syndrome or myeloproliferative neoplasm vary. The study emphasizes the importance of assessing spermatogonial numbers in patients with severe haematological diseases for informed fertility preservation decisions.

KW - bone marrow failure

KW - fertility

KW - immunodeficiency

KW - MDS

KW - myeloproliferative disease

KW - stem cell transplantation

UR - http://www.scopus.com/inward/record.url?scp=85194578908&partnerID=8YFLogxK

U2 - 10.1111/bjh.19572

DO - 10.1111/bjh.19572

M3 - Article

AN - SCOPUS:85194578908

SN - 0007-1048

VL - 205

SP - 229

EP - 235

JO - British Journal of Haematology

JF - British Journal of Haematology

IS - 1

ER -

Decreased spermatogonial numbers in boys with severe haematological diseases

Abstract

Bibliographical note

Other keywords

Access to Document

Fingerprint

Cite this