Cytotoxicity studies of water soluble coordination compounds with a [Mo 2 O 2 S 2 ] 2+ core

Jóhanna M. Grétarsdóttir; Sandra Bobersky; Nils Metzler-Nolte; Sigridur G Suman

doi:10.1016/j.jinorgbio.2016.01.020

Cytotoxicity studies of water soluble coordination compounds with a [Mo 2 O 2 S 2 ] 2+ core

Jóhanna M. Grétarsdóttir, Sandra Bobersky, Nils Metzler-Nolte, Sigridur G Suman

Research output: Contribution to journal › Article › peer-review

Abstract

Selected molybdenum sulfur compounds with the formulas (M)[Mo2O2S4L] where (Et4N)2(1), L = S42 −, (Et4N)(2), L = Cp, (3), L = DMF, K(5), L = serine, M = Et4N+, K+, Na+ and [Mo2O2S2L2] where Na2(4), L = cysteine, and (6), L = threonine, were prepared and subjected to cytotoxicity studies in vitro. The results were analyzed to rank the compounds according to their relative cytotoxicity and to correlate the observed toxicity to specific composition. The results guide future efforts to synthesize highly water soluble, non-toxic, compounds. Strong correlation was observed between toxicity and cation selection, as well as selection of biocompatible ligands combined with alkali metal salts. The most toxic compound analyzed showed about 50 times less cytotoxicity than the cisplatin reference compound in HT-29 cells. Preliminary results from in vivo data agree with the ranking obtained in vitro.

Original language	English
Pages (from-to)	166-171
Journal	Journal of Inorganic Biochemistry
Volume	160
DOIs	https://doi.org/10.1016/j.jinorgbio.2016.01.020
Publication status	Published - Jul 2016

Other keywords

Eiturefnafræði
Brennisteinn
Cytotoxicity
Molybdenum
Sulfur

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/j.jinorgbio.2016.01.020

https://hdl.handle.net/20.500.11815/1948Licence: CC BY-NC-SA

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@article{23773905f52147ea91002fdb86eb1bc7,

title = "Cytotoxicity studies of water soluble coordination compounds with a [Mo 2 O 2 S 2 ] 2+ core",

abstract = "Selected molybdenum sulfur compounds with the formulas (M)[Mo2O2S4L] where (Et4N)2(1), L = S42 −, (Et4N)(2), L = Cp, (3), L = DMF, K(5), L = serine, M = Et4N+, K+, Na+ and [Mo2O2S2L2] where Na2(4), L = cysteine, and (6), L = threonine, were prepared and subjected to cytotoxicity studies in vitro. The results were analyzed to rank the compounds according to their relative cytotoxicity and to correlate the observed toxicity to specific composition. The results guide future efforts to synthesize highly water soluble, non-toxic, compounds. Strong correlation was observed between toxicity and cation selection, as well as selection of biocompatible ligands combined with alkali metal salts. The most toxic compound analyzed showed about 50 times less cytotoxicity than the cisplatin reference compound in HT-29 cells. Preliminary results from in vivo data agree with the ranking obtained in vitro.",

keywords = "Eiturefnafr{\ae}{\dh}i, Brennisteinn, Cytotoxicity, Molybdenum, Sulfur, Eiturefnafr{\ae}{\dh}i, Brennisteinn, Cytotoxicity, Molybdenum, Sulfur",

author = "Gr{\'e}tarsd{\'o}ttir, {J{\'o}hanna M.} and Sandra Bobersky and Nils Metzler-Nolte and Suman, {Sigridur G}",

year = "2016",

month = jul,

doi = "10.1016/j.jinorgbio.2016.01.020",

language = "English",

volume = "160",

pages = "166--171",

journal = "Journal of Inorganic Biochemistry",

issn = "0162-0134",

publisher = "Elsevier Inc.",

}

TY - JOUR

T1 - Cytotoxicity studies of water soluble coordination compounds with a [Mo 2 O 2 S 2 ] 2+ core

AU - Grétarsdóttir, Jóhanna M.

AU - Bobersky, Sandra

AU - Metzler-Nolte, Nils

AU - Suman, Sigridur G

PY - 2016/7

Y1 - 2016/7

N2 - Selected molybdenum sulfur compounds with the formulas (M)[Mo2O2S4L] where (Et4N)2(1), L = S42 −, (Et4N)(2), L = Cp, (3), L = DMF, K(5), L = serine, M = Et4N+, K+, Na+ and [Mo2O2S2L2] where Na2(4), L = cysteine, and (6), L = threonine, were prepared and subjected to cytotoxicity studies in vitro. The results were analyzed to rank the compounds according to their relative cytotoxicity and to correlate the observed toxicity to specific composition. The results guide future efforts to synthesize highly water soluble, non-toxic, compounds. Strong correlation was observed between toxicity and cation selection, as well as selection of biocompatible ligands combined with alkali metal salts. The most toxic compound analyzed showed about 50 times less cytotoxicity than the cisplatin reference compound in HT-29 cells. Preliminary results from in vivo data agree with the ranking obtained in vitro.

AB - Selected molybdenum sulfur compounds with the formulas (M)[Mo2O2S4L] where (Et4N)2(1), L = S42 −, (Et4N)(2), L = Cp, (3), L = DMF, K(5), L = serine, M = Et4N+, K+, Na+ and [Mo2O2S2L2] where Na2(4), L = cysteine, and (6), L = threonine, were prepared and subjected to cytotoxicity studies in vitro. The results were analyzed to rank the compounds according to their relative cytotoxicity and to correlate the observed toxicity to specific composition. The results guide future efforts to synthesize highly water soluble, non-toxic, compounds. Strong correlation was observed between toxicity and cation selection, as well as selection of biocompatible ligands combined with alkali metal salts. The most toxic compound analyzed showed about 50 times less cytotoxicity than the cisplatin reference compound in HT-29 cells. Preliminary results from in vivo data agree with the ranking obtained in vitro.

KW - Eiturefnafræði

KW - Brennisteinn

KW - Cytotoxicity

KW - Molybdenum

KW - Sulfur

KW - Eiturefnafræði

KW - Brennisteinn

KW - Cytotoxicity

KW - Molybdenum

KW - Sulfur

U2 - 10.1016/j.jinorgbio.2016.01.020

DO - 10.1016/j.jinorgbio.2016.01.020

M3 - Article

SN - 0162-0134

VL - 160

SP - 166

EP - 171

JO - Journal of Inorganic Biochemistry

JF - Journal of Inorganic Biochemistry

ER -

Cytotoxicity studies of water soluble coordination compounds with a [Mo 2 O 2 S 2 ] 2+ core

Abstract

Other keywords

UN SDGs

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