Cytogenetics of myelodysplasia and acute myeloid leukaemia in aircrew and people treated with radiotherapy

Maryanne Gundestrup, Mette Klarskov Andersen, Erla Sveinbjornsdottir, V. Rafnsson, Hans H. Storm, Jens Pedersen-Bjergaard

Research output: Contribution to journalArticlepeer-review

Abstract

Increased risk of acute myeloid leukaemia has been reported in aircrew, possibly in association with cosmic radiation. We studied the cytogenetics of seven aircrew members who had acute myeloid leukaemia or myelodysplasia and found deletion or loss of chromosome 7 in four. The same abnormality was found in eight of 19 patients with leukaemia after radiotherapy alone. By comparison, only 81 of 761 unselected cases of myelodysplasia or acute myeloid leukaemia had the same cytogenetic abnormalities. Our results support the concept that deletions or loss of the long arm of chromosome 7 in myelodysplasia and acute myeloid leukaemia could indicate previous exposure to ionising radiation.

Original languageEnglish
Pages (from-to)2158
Number of pages1
JournalLancet
Volume356
Issue number9248
DOIs
Publication statusPublished - 2000

Fingerprint

Dive into the research topics of 'Cytogenetics of myelodysplasia and acute myeloid leukaemia in aircrew and people treated with radiotherapy'. Together they form a unique fingerprint.

Cite this