TY - JOUR
T1 - CRP is associated with lung function decline in men but not women
T2 - A prospective study
AU - Ólafsdóttir, Inga Sif
AU - Gíslason, Thórarinn
AU - Gudnason, Vilmundur
AU - Benediktsdóttir, Bryndís
AU - Ólafsson, Ísleifur
AU - Aspelund, Thor
AU - Thjódleifsson, Bjarni
AU - Janson, Christer
N1 - Funding Information:
This study was supported financially by Icelandic Research Council grant no. 050405011 and The Landspitali-University Hospital Research Fund . Special thanks to María Gunnbjörndóttir and Sue Pajuluoma for reviewing the article.
PY - 2013/1
Y1 - 2013/1
N2 - Systemic inflammation is associated with impaired lung function. Studies, most cross-sectional, report a stronger association between systemic inflammation and lung function impairment in men than women. The aim was to evaluate gender differences in the longitudinal association between systemic inflammation and lung function. We used data from randomly chosen residents of Reykjavík, born 1940-54, who were investigated in three stages: Baseline (1973-75; 1983-85) and follow-up (2001-03). The participants (n = 1049, 574 women) had a mean age of 28 ± 6 years at baseline and mean follow-up time of 27 ± 4 years. At each stage lung function (FEV1 and FVC) and C-reactive protein (CRP) were evaluated. Change in FEV1 (p = 0.04) and FVC (p = 0.01) was associated with baseline CRP in men but not in women. In the multiple variable analysis, CRP at baseline was associated with a decline in FEV1 (-3.1 mL/year, 95% CI: -5.1, -0.99) and FVC (-2.5 mL/year, 95% CI: -4.4, -0.65) in men but not in women. Similarly during follow-up, change in CRP, standardised to 1SD, was associated with a decline in FEV1 (-0.19 mL/year, 95% CI: -0.30, -0.07) and FVC (-0.11 mL/year, 95% CI: -0.22, -0.01)) in men but not in women. This prospective study confirms a stronger association between systemic inflammation and lung function decline in men than in women. This may indicate a gender difference in the mechanisms of lung function decline.
AB - Systemic inflammation is associated with impaired lung function. Studies, most cross-sectional, report a stronger association between systemic inflammation and lung function impairment in men than women. The aim was to evaluate gender differences in the longitudinal association between systemic inflammation and lung function. We used data from randomly chosen residents of Reykjavík, born 1940-54, who were investigated in three stages: Baseline (1973-75; 1983-85) and follow-up (2001-03). The participants (n = 1049, 574 women) had a mean age of 28 ± 6 years at baseline and mean follow-up time of 27 ± 4 years. At each stage lung function (FEV1 and FVC) and C-reactive protein (CRP) were evaluated. Change in FEV1 (p = 0.04) and FVC (p = 0.01) was associated with baseline CRP in men but not in women. In the multiple variable analysis, CRP at baseline was associated with a decline in FEV1 (-3.1 mL/year, 95% CI: -5.1, -0.99) and FVC (-2.5 mL/year, 95% CI: -4.4, -0.65) in men but not in women. Similarly during follow-up, change in CRP, standardised to 1SD, was associated with a decline in FEV1 (-0.19 mL/year, 95% CI: -0.30, -0.07) and FVC (-0.11 mL/year, 95% CI: -0.22, -0.01)) in men but not in women. This prospective study confirms a stronger association between systemic inflammation and lung function decline in men than in women. This may indicate a gender difference in the mechanisms of lung function decline.
KW - FEV
KW - FEV decline
KW - FVC
KW - Gender difference
KW - Lung function
KW - Systemic inflammation
UR - http://www.scopus.com/inward/record.url?scp=84871359816&partnerID=8YFLogxK
U2 - 10.1016/j.rmed.2012.09.020
DO - 10.1016/j.rmed.2012.09.020
M3 - Article
C2 - 23083841
AN - SCOPUS:84871359816
SN - 0954-6111
VL - 107
SP - 91
EP - 97
JO - Respiratory Medicine
JF - Respiratory Medicine
IS - 1
ER -