Coupling multiscale X-ray physics and micromechanics for bone tissue composition and elasticity determination from micro-CT data, by example of femora from OVX and sham rats

Patricia Hasslinger; Viktoria Vass; Alexander Dejaco; Romane Blanchard; Gissur Örlygsson; Paolo Gargiulo; Christian Hellmich

doi:10.1080/15502287.2016.1145762

Coupling multiscale X-ray physics and micromechanics for bone tissue composition and elasticity determination from micro-CT data, by example of femora from OVX and sham rats

Patricia Hasslinger, Viktoria Vass, Alexander Dejaco, Romane Blanchard, Gissur Örlygsson, Paolo Gargiulo, Christian Hellmich^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

6 Citations (Scopus)

Abstract

ABSTRACT: Due to its high resolution, micro-CT (Computed Tomograph) scanning is the key to assess bone quality of sham and OVX (ovariectomized) rats. Combination of basic X-ray physics, such as the energy- and chemistry-dependence of attenuation coefficients, with results from ashing tests on rat bones, delivers mineral, organic, and water volume fractions within the voxels. Additional use of a microelastic model for bone provides voxel-specific elastic properties. The new method delivers realistic bone mass densities, and reveals that OVX protocols may indeed induce some bone mass loss, while the average composition of the bone tissue remains largely unaltered.

Original language	English
Pages (from-to)	222-244
Number of pages	23
Journal	International Journal for Computational Methods in Engineering Science and Mechanics
Volume	17
Issue number	3
DOIs	https://doi.org/10.1080/15502287.2016.1145762
Publication status	Published - 3 May 2016

Bibliographical note

Publisher Copyright:
© 2016 Taylor & Francis Group, LLC.

Other keywords

Extracellular bone matrix
mechanical behavior
micro-CT
multiscale modeling
osteoporosis
X-ray physics
Beinþynning
RES12
X-Rays
X-Ray Microtomography
Bone Matrix

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10.1080/15502287.2016.1145762

http://www.tandfonline.com/doi/full/10.1080/15502287.2016.1145762

Cite this

Hasslinger, P., Vass, V., Dejaco, A., Blanchard, R., Örlygsson, G., Gargiulo, P., & Hellmich, C. (2016). Coupling multiscale X-ray physics and micromechanics for bone tissue composition and elasticity determination from micro-CT data, by example of femora from OVX and sham rats. International Journal for Computational Methods in Engineering Science and Mechanics, 17(3), 222-244. https://doi.org/10.1080/15502287.2016.1145762

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abstract = "ABSTRACT: Due to its high resolution, micro-CT (Computed Tomograph) scanning is the key to assess bone quality of sham and OVX (ovariectomized) rats. Combination of basic X-ray physics, such as the energy- and chemistry-dependence of attenuation coefficients, with results from ashing tests on rat bones, delivers mineral, organic, and water volume fractions within the voxels. Additional use of a microelastic model for bone provides voxel-specific elastic properties. The new method delivers realistic bone mass densities, and reveals that OVX protocols may indeed induce some bone mass loss, while the average composition of the bone tissue remains largely unaltered.",

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author = "Patricia Hasslinger and Viktoria Vass and Alexander Dejaco and Romane Blanchard and Gissur {\"O}rlygsson and Paolo Gargiulo and Christian Hellmich",

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Hasslinger, P, Vass, V, Dejaco, A, Blanchard, R, Örlygsson, G, Gargiulo, P & Hellmich, C 2016, 'Coupling multiscale X-ray physics and micromechanics for bone tissue composition and elasticity determination from micro-CT data, by example of femora from OVX and sham rats', International Journal for Computational Methods in Engineering Science and Mechanics, vol. 17, no. 3, pp. 222-244. https://doi.org/10.1080/15502287.2016.1145762

Coupling multiscale X-ray physics and micromechanics for bone tissue composition and elasticity determination from micro-CT data, by example of femora from OVX and sham rats. / Hasslinger, Patricia; Vass, Viktoria; Dejaco, Alexander et al.
In: International Journal for Computational Methods in Engineering Science and Mechanics, Vol. 17, No. 3, 03.05.2016, p. 222-244.

Research output: Contribution to journal › Article › peer-review

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AU - Hasslinger, Patricia

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AU - Blanchard, Romane

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AB - ABSTRACT: Due to its high resolution, micro-CT (Computed Tomograph) scanning is the key to assess bone quality of sham and OVX (ovariectomized) rats. Combination of basic X-ray physics, such as the energy- and chemistry-dependence of attenuation coefficients, with results from ashing tests on rat bones, delivers mineral, organic, and water volume fractions within the voxels. Additional use of a microelastic model for bone provides voxel-specific elastic properties. The new method delivers realistic bone mass densities, and reveals that OVX protocols may indeed induce some bone mass loss, while the average composition of the bone tissue remains largely unaltered.

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KW - Beinþynning

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Hasslinger P, Vass V, Dejaco A, Blanchard R, Örlygsson G, Gargiulo P et al. Coupling multiscale X-ray physics and micromechanics for bone tissue composition and elasticity determination from micro-CT data, by example of femora from OVX and sham rats. International Journal for Computational Methods in Engineering Science and Mechanics. 2016 May 3;17(3):222-244. doi: 10.1080/15502287.2016.1145762

Coupling multiscale X-ray physics and micromechanics for bone tissue composition and elasticity determination from micro-CT data, by example of femora from OVX and sham rats

Abstract

Bibliographical note

Other keywords

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