Comparative Treatment Outcomes for Idiopathic Subglottic Stenosis: 5-Year Update

William S Tierney, Li-Ching Huang, Sheau-Chiann Chen, Lynn D Berry, Catherine Anderson, Milan R Amin, Michael S Benninger, Joel H Blumin, Jonathan M Bock, Paul C Bryson, Paul F Castellanos, Matthew S Clary, Seth M Cohen, Brianna K Crawley, Seth H Dailey, James J Daniero, Alessandro de Alarcon, Donald T Donovan, Eric S Edell, Dale C EkbomDaniel S Fink, Ramon A Franco, Catherine Gaelyn Garrett, Elizabeth A Guardiani, Alexander T Hillel, Henry T Hoffman, Norman D Hogikyan, Rebecca J Howell, Michael M Johns, Jan L Kasperbauer, Sid M Khosla, Cheryl Kinnard, Robbi A Kupfer, Alexander J Langerman, Robert J Lentz, Robert R Lorenz, David G Lott, Samir S Makani, Fabien Maldonado, Laura Matrka, Andrew J McWhorter, Albert L Merati, Matthew Mori, James L Netterville, Karla O'Dell, Julina Ongkasuwan, Gregory N Postma, Lindsay S Reder, Sarah L Rohde, Brent E Richardson, Otis B Rickman, Clark A Rosen, Matthew Rohlfing, Michael J Rutter, Guri S Sandhu, Joshua S Schindler, Glenn Todd Schneider, Rupali N Shah, Andrew G Sikora, Robert J Sinard, Marshall E Smith, Libby J Smith, Ahmed M S Soliman, Sigríður Sveinsdóttir, David Veivers, Sunil P Verma, Paul M Weinberger, Philip A Weissbrod, Christopher T Wootten, Yu Shyr, David O Francis, Alexander Gelbard

Research output: Contribution to journalArticlepeer-review


The North American Airway Collaborative (NoAAC) previously published a 3-year multi-institutional prospective cohort study showing variation in treatment effectiveness between 3 primary surgical techniques for idiopathic subglottic stenosis (iSGS). In this report, we update these findings to include 5 years of data evaluating treatment effectiveness. Patients in the NoAAC cohort were re-enrolled for 2 additional years and followed using the prespecified published protocol. Consistent with prior data, prospective observation of 487 iSGS patients for 5 years showed treatment effectiveness differed by modality. Cricotracheal resection maintained the lowest rate of recurrent operation (5%), followed by endoscopic resection with adjuvant medical therapy (30%) and endoscopic dilation (50%). These data support the initial observations and continue to provide value to providers and patients navigating longitudinal decision-making. Level of evidence: 2-prospective cohort study.

Original languageEnglish
Pages (from-to)1570-1575
Number of pages6
JournalOtolaryngology - Head and Neck Surgery
Issue number6
Early online date19 Jan 2023
Publication statusPublished - Jun 2023

Bibliographical note

Funding Information:
The original 3‐year prospective study was funded by the Patient Centered Outcomes Institute (PCORI) grant number 140922214.

Publisher Copyright:
© 2023 American Academy of Otolaryngology–Head and Neck Surgery Foundation.

Other keywords

  • Constriction, Pathologic
  • Humans
  • Laryngostenosis/surgery
  • Prospective Studies
  • Retrospective Studies
  • Treatment Outcome
  • iSGS
  • dyspnea
  • subglottic stenosis
  • cricotracheal
  • dilation
  • idiopathic
  • tracheal resection
  • laryngology
  • endoscopic resection


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