Co-occurrence of major depression or suicide attempt with migraine with aura and risk for unprovoked seizure

Dale C. Hesdorffer*, Pétur Lúdvígsson, W. Allen Hauser, Elías Ólafsson, Ólafur Kjartansson

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

34 Citations (Scopus)

Abstract

We hypothesized and found that the co-occurrence of migraine with aura (MA) with major depression (MD) or with suicide attempt (SA) increases the risk for developing unprovoked seizure more than these conditions alone. Number of conditions showed a linear relationship to seizure risk. This may reflect a new condition cluster defined by MA, MD, SA and unprovoked seizures. Identifying the biological underpinnings this cluster may affect clinical diagnosis and treatment.

Original languageEnglish
Pages (from-to)220-223
Number of pages4
JournalEpilepsy Research
Volume75
Issue number2-3
DOIs
Publication statusPublished - Jul 2007

Bibliographical note

Funding Information:
Funding and disclosures : This work was supported by a grant from the National Institute of Neurological Disorders and Stroke (5R01 NS 32663). The authors thank Ingigerđur Olafsdóttir, Oddńy Gunnarsdóttir, and Ingibjörg Einarsdóttir for their assistance with the study. We are grateful also to Drs. Mervyn Susser and Anne T. Berg for their critical reading of the manuscript.

Other keywords

  • Case-control study
  • Depression
  • Epilepsy
  • Migraine
  • Unprovoked seizure

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