Circulating adhesion molecules in allergic and non-allergic asthma

Christer Janson; Dora Ludviksdottir; María Gunnbjörnsdottir; Eythor H. Björnsson; Lena Håkansson; Per Venge; Anders Ahlander; Kawa Amin; Gunnar Boman; Britt Marie Eriksson; Björn Gudbjörnsson; Monika Hall; Göran Hedenstierna; Hans Hedenström; Marieann Högman; Maria Lampinen; Kerstin Lindblad; Otto Nettelbladt; Godfried Roomans; Lahja Sevèus; A. Ulrike-Spetz-Nyström; Gunnemar Stålenheim; Sigrídur Valtýsdóttir; Charlotte Woschnagg

doi:10.1016/j.rmed.2004.05.007

Circulating adhesion molecules in allergic and non-allergic asthma

Christer Janson^*, Dora Ludviksdottir, María Gunnbjörnsdottir, Eythor H. Björnsson, Lena Håkansson, Per Venge, Anders Ahlander, Kawa Amin, Gunnar Boman, Britt Marie Eriksson, Björn Gudbjörnsson, Monika Hall, Göran Hedenstierna, Hans Hedenström, Marieann Högman, Maria Lampinen, Kerstin Lindblad, Otto Nettelbladt, Godfried Roomans, Lahja SevèusA. Ulrike-Spetz-Nyström, Gunnemar Stålenheim, Sigrídur Valtýsdóttir, Charlotte Woschnagg

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

20 Citations (Scopus)

Abstract

Circulating forms of adhesion molecules (intercellular-adhesion molecule-1 (ICAM-1), vascular cell adhesion molecule-1 (VCAM-1) and E-selectin ) are related to the turnover of these molecules on the cell surface. In contrast to the other molecules, the levels of E-selectin probably exclusively reflect the activity of endothelial cells. The aim of this study was to compare levels of circulating adhesion molecules in patients with allergic (AA) and non-allergic asthma (NA) and to relate the levels of soluble adhesion molecules to methacholine responsiveness and lung function. The study comprised 19 patients with AA, 15 patients with NA and 17 healthy subjects. Soluble adhesion molecules, spirometry, methacholine responsiveness and peak flow variability was measured. The group of patients with AA had higher levels of sE-selectin than the reference group (P=0.046). Serum levels of sE-selectin correlated significantly with bronchial responsiveness (r=0.76) and peak flow variability (r=0.75) (P<0.01) in the NA but not in the AA group. All adhesion molecules in AA (P<0.05-<0.001), but only sE-selectin in NA (P<0.05), were correlated to airway conductance. sVCAM-1 was reduced by inhaled steroids (P<0.01). Our results indicate that endothelial cells are activated in asthma and that this activity has a bearing on airflow variability and bronchial responsiveness in NA.

Original language	English
Pages (from-to)	45-51
Number of pages	7
Journal	Respiratory Medicine
Volume	99
Issue number	1
DOIs	https://doi.org/10.1016/j.rmed.2004.05.007
Publication status	Published - Jan 2005

Bibliographical note

Funding Information:
We thank our research nurse Ulrike Spetz-Nyström and research technician Monica Hall for their assistance with collecting data and technical assistance with the bronchial challenges. We acknowledge the support of the Swedish Heart–Lung Foundation, the King Oscar II Jubilee Foundation, and the Bror Hjerpstedt Foundation.

Other keywords

Adhesion molecules
Allergy
Asthma
Bronchial responsiveness

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10.1016/j.rmed.2004.05.007

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Janson, C., Ludviksdottir, D., Gunnbjörnsdottir, M., Björnsson, E. H., Håkansson, L., Venge, P., Ahlander, A., Amin, K., Boman, G., Eriksson, B. M., Gudbjörnsson, B., Hall, M., Hedenstierna, G., Hedenström, H., Högman, M., Lampinen, M., Lindblad, K., Nettelbladt, O., Roomans, G., ... Woschnagg, C. (2005). Circulating adhesion molecules in allergic and non-allergic asthma. Respiratory Medicine, 99(1), 45-51. https://doi.org/10.1016/j.rmed.2004.05.007

@article{64698f2995cd44f59af89b1b07feaee0,

title = "Circulating adhesion molecules in allergic and non-allergic asthma",

abstract = "Circulating forms of adhesion molecules (intercellular-adhesion molecule-1 (ICAM-1), vascular cell adhesion molecule-1 (VCAM-1) and E-selectin ) are related to the turnover of these molecules on the cell surface. In contrast to the other molecules, the levels of E-selectin probably exclusively reflect the activity of endothelial cells. The aim of this study was to compare levels of circulating adhesion molecules in patients with allergic (AA) and non-allergic asthma (NA) and to relate the levels of soluble adhesion molecules to methacholine responsiveness and lung function. The study comprised 19 patients with AA, 15 patients with NA and 17 healthy subjects. Soluble adhesion molecules, spirometry, methacholine responsiveness and peak flow variability was measured. The group of patients with AA had higher levels of sE-selectin than the reference group (P=0.046). Serum levels of sE-selectin correlated significantly with bronchial responsiveness (r=0.76) and peak flow variability (r=0.75) (P<0.01) in the NA but not in the AA group. All adhesion molecules in AA (P<0.05-<0.001), but only sE-selectin in NA (P<0.05), were correlated to airway conductance. sVCAM-1 was reduced by inhaled steroids (P<0.01). Our results indicate that endothelial cells are activated in asthma and that this activity has a bearing on airflow variability and bronchial responsiveness in NA.",

keywords = "Adhesion molecules, Allergy, Asthma, Bronchial responsiveness",

author = "Christer Janson and Dora Ludviksdottir and Mar{\'i}a Gunnbj{\"o}rnsdottir and Bj{\"o}rnsson, {Eythor H.} and Lena H{\aa}kansson and Per Venge and Anders Ahlander and Kawa Amin and Gunnar Boman and Eriksson, {Britt Marie} and Bj{\"o}rn Gudbj{\"o}rnsson and Monika Hall and G{\"o}ran Hedenstierna and Hans Hedenstr{\"o}m and Marieann H{\"o}gman and Maria Lampinen and Kerstin Lindblad and Otto Nettelbladt and Godfried Roomans and Lahja Sev{\`e}us and A. Ulrike-Spetz-Nystr{\"o}m and Gunnemar St{\aa}lenheim and Sigr{\'i}dur Valt{\'y}sd{\'o}ttir and Charlotte Woschnagg",

note = "Funding Information: We thank our research nurse Ulrike Spetz-Nystr{\"o}m and research technician Monica Hall for their assistance with collecting data and technical assistance with the bronchial challenges. We acknowledge the support of the Swedish Heart–Lung Foundation, the King Oscar II Jubilee Foundation, and the Bror Hjerpstedt Foundation.",

year = "2005",

month = jan,

doi = "10.1016/j.rmed.2004.05.007",

language = "English",

volume = "99",

pages = "45--51",

journal = "Respiratory Medicine",

issn = "0954-6111",

publisher = "W.B. Saunders Ltd",

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Janson, C, Ludviksdottir, D, Gunnbjörnsdottir, M, Björnsson, EH, Håkansson, L, Venge, P, Ahlander, A, Amin, K, Boman, G, Eriksson, BM, Gudbjörnsson, B, Hall, M, Hedenstierna, G, Hedenström, H, Högman, M, Lampinen, M, Lindblad, K, Nettelbladt, O, Roomans, G, Sevèus, L, Ulrike-Spetz-Nyström, A, Stålenheim, G, Valtýsdóttir, S & Woschnagg, C 2005, 'Circulating adhesion molecules in allergic and non-allergic asthma', Respiratory Medicine, vol. 99, no. 1, pp. 45-51. https://doi.org/10.1016/j.rmed.2004.05.007

TY - JOUR

T1 - Circulating adhesion molecules in allergic and non-allergic asthma

AU - Janson, Christer

AU - Ludviksdottir, Dora

AU - Gunnbjörnsdottir, María

AU - Björnsson, Eythor H.

AU - Håkansson, Lena

AU - Venge, Per

AU - Ahlander, Anders

AU - Amin, Kawa

AU - Boman, Gunnar

AU - Eriksson, Britt Marie

AU - Gudbjörnsson, Björn

AU - Hall, Monika

AU - Hedenstierna, Göran

AU - Hedenström, Hans

AU - Högman, Marieann

AU - Lampinen, Maria

AU - Lindblad, Kerstin

AU - Nettelbladt, Otto

AU - Roomans, Godfried

AU - Sevèus, Lahja

AU - Ulrike-Spetz-Nyström, A.

AU - Stålenheim, Gunnemar

AU - Valtýsdóttir, Sigrídur

AU - Woschnagg, Charlotte

N1 - Funding Information: We thank our research nurse Ulrike Spetz-Nyström and research technician Monica Hall for their assistance with collecting data and technical assistance with the bronchial challenges. We acknowledge the support of the Swedish Heart–Lung Foundation, the King Oscar II Jubilee Foundation, and the Bror Hjerpstedt Foundation.

PY - 2005/1

Y1 - 2005/1

N2 - Circulating forms of adhesion molecules (intercellular-adhesion molecule-1 (ICAM-1), vascular cell adhesion molecule-1 (VCAM-1) and E-selectin ) are related to the turnover of these molecules on the cell surface. In contrast to the other molecules, the levels of E-selectin probably exclusively reflect the activity of endothelial cells. The aim of this study was to compare levels of circulating adhesion molecules in patients with allergic (AA) and non-allergic asthma (NA) and to relate the levels of soluble adhesion molecules to methacholine responsiveness and lung function. The study comprised 19 patients with AA, 15 patients with NA and 17 healthy subjects. Soluble adhesion molecules, spirometry, methacholine responsiveness and peak flow variability was measured. The group of patients with AA had higher levels of sE-selectin than the reference group (P=0.046). Serum levels of sE-selectin correlated significantly with bronchial responsiveness (r=0.76) and peak flow variability (r=0.75) (P<0.01) in the NA but not in the AA group. All adhesion molecules in AA (P<0.05-<0.001), but only sE-selectin in NA (P<0.05), were correlated to airway conductance. sVCAM-1 was reduced by inhaled steroids (P<0.01). Our results indicate that endothelial cells are activated in asthma and that this activity has a bearing on airflow variability and bronchial responsiveness in NA.

AB - Circulating forms of adhesion molecules (intercellular-adhesion molecule-1 (ICAM-1), vascular cell adhesion molecule-1 (VCAM-1) and E-selectin ) are related to the turnover of these molecules on the cell surface. In contrast to the other molecules, the levels of E-selectin probably exclusively reflect the activity of endothelial cells. The aim of this study was to compare levels of circulating adhesion molecules in patients with allergic (AA) and non-allergic asthma (NA) and to relate the levels of soluble adhesion molecules to methacholine responsiveness and lung function. The study comprised 19 patients with AA, 15 patients with NA and 17 healthy subjects. Soluble adhesion molecules, spirometry, methacholine responsiveness and peak flow variability was measured. The group of patients with AA had higher levels of sE-selectin than the reference group (P=0.046). Serum levels of sE-selectin correlated significantly with bronchial responsiveness (r=0.76) and peak flow variability (r=0.75) (P<0.01) in the NA but not in the AA group. All adhesion molecules in AA (P<0.05-<0.001), but only sE-selectin in NA (P<0.05), were correlated to airway conductance. sVCAM-1 was reduced by inhaled steroids (P<0.01). Our results indicate that endothelial cells are activated in asthma and that this activity has a bearing on airflow variability and bronchial responsiveness in NA.

KW - Adhesion molecules

KW - Allergy

KW - Asthma

KW - Bronchial responsiveness

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SP - 45

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JO - Respiratory Medicine

JF - Respiratory Medicine

IS - 1

ER -

Circulating adhesion molecules in allergic and non-allergic asthma

Abstract

Bibliographical note

Other keywords

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