Cerebral sinus venous thromboses in children with acute lymphoblastic leukaemia - a multicentre study from the Nordic Society of Paediatric Haematology and Oncology.

Susanna Ranta; Ruta Tuckuviene; Anne Mäkipernaa; Birgitte K Albertsen; Tony Frisk; Ulf Tedgård; Ólafur G Jónsson; Kaie Pruunsild; Nadine Gretenkort Andersson; Maria Winther Gunnes; Sonata Saulyte Trakymiene; Thomas Frandsen; Mats Heyman; Ellen Ruud; Jon Helgestad

doi:10.1111/bjh.13162

Cerebral sinus venous thromboses in children with acute lymphoblastic leukaemia - a multicentre study from the Nordic Society of Paediatric Haematology and Oncology.

Susanna Ranta, Ruta Tuckuviene, Anne Mäkipernaa, Birgitte K Albertsen, Tony Frisk, Ulf Tedgård, Ólafur G Jónsson, Kaie Pruunsild, Nadine Gretenkort Andersson, Maria Winther Gunnes, Sonata Saulyte Trakymiene, Thomas Frandsen, Mats Heyman, Ellen Ruud, Jon Helgestad

Landspitali - The National University Hospital of Iceland

Research output: Contribution to journal › Article › peer-review

Abstract

We present a prospective multicentre cohort of 20 children with acute lymphoblastic leukaemia (ALL) and cerebral sinus venous thrombosis (CSVT). The study covers a period of 5 years and comprises 1038 children treated according to the Nordic Society of Paediatric Haematology and Oncology (NOPHO) ALL 2008 protocol. The cumulative incidence of CSVT was 2%. Sixteen of the thromboses were related to asparaginase and 16 to steroids. Most CSVTs occurred in the consolidation phase. Nearly all were treated with low molecular weight heparin without bleeding complications. Mortality related to CSVT directly or indirectly was 10%, emphasizing the importance of this complication.

Original language	English
Journal	British Journal of Haematology
DOIs	https://doi.org/10.1111/bjh.13162
Publication status	Published - Feb 2015

Other keywords

Hvítblæði
Börn
Adolescent
Adrenal Cortex Hormones
Anticoagulants
Antineoplastic Combined Chemotherapy Protocols
Asparaginase
Baltic States
Child
Child, Preschool
Consolidation Chemotherapy
Female
Humans
Incidence
Infant
Male
Precursor Cell Lymphoblastic Leukemia-Lymphoma
Prospective Studies
Risk Factors
Scandinavian and Nordic Countries
Sinus Thrombosis, Intracranial
Treatment Outcome

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10.1111/bjh.13162

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Ranta, S., Tuckuviene, R., Mäkipernaa, A., Albertsen, B. K., Frisk, T., Tedgård, U., Jónsson, Ó. G., Pruunsild, K., Gretenkort Andersson, N., Winther Gunnes, M., Saulyte Trakymiene, S., Frandsen, T., Heyman, M., Ruud, E., & Helgestad, J. (2015). Cerebral sinus venous thromboses in children with acute lymphoblastic leukaemia - a multicentre study from the Nordic Society of Paediatric Haematology and Oncology. British Journal of Haematology. https://doi.org/10.1111/bjh.13162

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title = "Cerebral sinus venous thromboses in children with acute lymphoblastic leukaemia - a multicentre study from the Nordic Society of Paediatric Haematology and Oncology.",

abstract = "We present a prospective multicentre cohort of 20 children with acute lymphoblastic leukaemia (ALL) and cerebral sinus venous thrombosis (CSVT). The study covers a period of 5 years and comprises 1038 children treated according to the Nordic Society of Paediatric Haematology and Oncology (NOPHO) ALL 2008 protocol. The cumulative incidence of CSVT was 2%. Sixteen of the thromboses were related to asparaginase and 16 to steroids. Most CSVTs occurred in the consolidation phase. Nearly all were treated with low molecular weight heparin without bleeding complications. Mortality related to CSVT directly or indirectly was 10%, emphasizing the importance of this complication.",

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author = "Susanna Ranta and Ruta Tuckuviene and Anne M{\"a}kipernaa and Albertsen, {Birgitte K} and Tony Frisk and Ulf Tedg{\aa}rd and J{\'o}nsson, {{\'O}lafur G} and Kaie Pruunsild and {Gretenkort Andersson}, Nadine and {Winther Gunnes}, Maria and {Saulyte Trakymiene}, Sonata and Thomas Frandsen and Mats Heyman and Ellen Ruud and Jon Helgestad",

year = "2015",

month = feb,

doi = "10.1111/bjh.13162",

language = "English",

journal = "British Journal of Haematology",

issn = "0007-1048",

publisher = "Wiley-Blackwell Publishing Ltd",

}

Ranta, S, Tuckuviene, R, Mäkipernaa, A, Albertsen, BK, Frisk, T, Tedgård, U, Jónsson, ÓG, Pruunsild, K, Gretenkort Andersson, N, Winther Gunnes, M, Saulyte Trakymiene, S, Frandsen, T, Heyman, M, Ruud, E & Helgestad, J 2015, 'Cerebral sinus venous thromboses in children with acute lymphoblastic leukaemia - a multicentre study from the Nordic Society of Paediatric Haematology and Oncology.', British Journal of Haematology. https://doi.org/10.1111/bjh.13162

TY - JOUR

T1 - Cerebral sinus venous thromboses in children with acute lymphoblastic leukaemia - a multicentre study from the Nordic Society of Paediatric Haematology and Oncology.

AU - Ranta, Susanna

AU - Tuckuviene, Ruta

AU - Mäkipernaa, Anne

AU - Albertsen, Birgitte K

AU - Frisk, Tony

AU - Tedgård, Ulf

AU - Jónsson, Ólafur G

AU - Pruunsild, Kaie

AU - Gretenkort Andersson, Nadine

AU - Winther Gunnes, Maria

AU - Saulyte Trakymiene, Sonata

AU - Frandsen, Thomas

AU - Heyman, Mats

AU - Ruud, Ellen

AU - Helgestad, Jon

PY - 2015/2

Y1 - 2015/2

N2 - We present a prospective multicentre cohort of 20 children with acute lymphoblastic leukaemia (ALL) and cerebral sinus venous thrombosis (CSVT). The study covers a period of 5 years and comprises 1038 children treated according to the Nordic Society of Paediatric Haematology and Oncology (NOPHO) ALL 2008 protocol. The cumulative incidence of CSVT was 2%. Sixteen of the thromboses were related to asparaginase and 16 to steroids. Most CSVTs occurred in the consolidation phase. Nearly all were treated with low molecular weight heparin without bleeding complications. Mortality related to CSVT directly or indirectly was 10%, emphasizing the importance of this complication.

AB - We present a prospective multicentre cohort of 20 children with acute lymphoblastic leukaemia (ALL) and cerebral sinus venous thrombosis (CSVT). The study covers a period of 5 years and comprises 1038 children treated according to the Nordic Society of Paediatric Haematology and Oncology (NOPHO) ALL 2008 protocol. The cumulative incidence of CSVT was 2%. Sixteen of the thromboses were related to asparaginase and 16 to steroids. Most CSVTs occurred in the consolidation phase. Nearly all were treated with low molecular weight heparin without bleeding complications. Mortality related to CSVT directly or indirectly was 10%, emphasizing the importance of this complication.

KW - Hvítblæði

KW - Börn

KW - Adolescent

KW - Adrenal Cortex Hormones

KW - Anticoagulants

KW - Antineoplastic Combined Chemotherapy Protocols

KW - Asparaginase

KW - Baltic States

KW - Child

KW - Child, Preschool

KW - Consolidation Chemotherapy

KW - Female

KW - Humans

KW - Incidence

KW - Infant

KW - Male

KW - Precursor Cell Lymphoblastic Leukemia-Lymphoma

KW - Prospective Studies

KW - Risk Factors

KW - Scandinavian and Nordic Countries

KW - Sinus Thrombosis, Intracranial

KW - Treatment Outcome

KW - Hvítblæði

KW - Börn

KW - Adolescent

KW - Adrenal Cortex Hormones

KW - Anticoagulants

KW - Antineoplastic Combined Chemotherapy Protocols

KW - Asparaginase

KW - Baltic States

KW - Child

KW - Child, Preschool

KW - Consolidation Chemotherapy

KW - Female

KW - Humans

KW - Incidence

KW - Infant

KW - Male

KW - Precursor Cell Lymphoblastic Leukemia-Lymphoma

KW - Prospective Studies

KW - Risk Factors

KW - Scandinavian and Nordic Countries

KW - Sinus Thrombosis, Intracranial

KW - Treatment Outcome

U2 - 10.1111/bjh.13162

DO - 10.1111/bjh.13162

M3 - Article

C2 - 25288392

SN - 0007-1048

JO - British Journal of Haematology

JF - British Journal of Haematology

ER -

Cerebral sinus venous thromboses in children with acute lymphoblastic leukaemia - a multicentre study from the Nordic Society of Paediatric Haematology and Oncology.

Abstract

Other keywords

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