Breast cancer risk associated with AURKA 91T → A polymorphism in relation to BRCA mutations

Linda Vidarsdottir, Sigridur K. Bodvarsdottir, Holmfridur Hilmarsdottir, Laufey Tryggvadottir, Jorunn E. Eyfjord*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

25 Citations (Scopus)

Abstract

In this study 759 breast cancer patients, including 9 BRCA1 and 98 BRCA2 mutation carriers, and 653 mutation-negative unaffected controls were genotyped for the AURKA 91T → A polymorphism. Individuals homozygous for the 91A allele were found to be at increased risk of breast cancer compared to 91T homozygotes (OR = 1.87; 95% CI = 1.09-3.21). This association was strengthened when cases carrying BRCA mutations were excluded (OR = 2.00; 95% CI = 1.15-3.47). BRCA carrier cases differed from sporadic cases and their allele distribution was very similar to controls. These results show a statistically significant increased risk of sporadic breast cancer for individuals that are homozygous for the 91A allele but no effect in carriers of BRCA mutations. This may throw light on previously conflicting results.

Original languageEnglish
Pages (from-to)206-212
Number of pages7
JournalCancer Letters
Volume250
Issue number2
DOIs
Publication statusPublished - 8 Jun 2007

Bibliographical note

Funding Information:
The authors thank the Department of Pathology and the Icelandic Cancer Society Biobank for supplying samples, Gudridur Olafsdottir for data management, Jon G. Jonasson for information on hormone receptor status, Elinborg Olafsdottir, Rafn Sigurdsson and Olafur A. Stefansson for statistical analysis. This work was supported by the Icelandic Research Fund for graduate students (L. Vidarsdottir), the Memorial Fund of Bergthora Magnusdottir and Jakob Bjarnason (L. Vidarsdottir), the Icelandic Student Innovation Fund (L. Vidarsdottir), the Research Fund of the University of Iceland, the Memorial Fund of Margret Bjorgolfsdottir and the Icelandic Science Foundation (RANNIS). Last but not least we thank all the participants for their contribution.

Other keywords

  • Allele-specific amplification
  • Aurora kinase A polymorphism
  • BRCA
  • Breast cancer risk
  • Hormone receptor status

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