Brain tissue volumes by APOE genotype and leisure activity-the AGES-Reykjavik Study

Sigridur Harpa Hafsteinsdottir; Gudny Eiriksdottir; Sigurdur Sigurdsson; Thor Aspelund; Tamara B. Harris; Lenore J. Launer; Vilmundur Gudnason

doi:10.1016/j.neurobiolaging.2011.06.028

Brain tissue volumes by APOE genotype and leisure activity-the AGES-Reykjavik Study

Sigridur Harpa Hafsteinsdottir^*, Gudny Eiriksdottir, Sigurdur Sigurdsson, Thor Aspelund, Tamara B. Harris, Lenore J. Launer, Vilmundur Gudnason

^*Corresponding author for this work

Faculty of Medicine

Research output: Contribution to journal › Article › peer-review

10 Citations (Scopus)

Abstract

This study investigates the association of the APOE ε4 allele and leisure activity with brain tissue volumes, including white matter hyperintensities (WMH), in a population-based cohort of 4303 nondemented individuals, aged 66-96 years. APOE ε4 carriers were shown to have greater WMH and cerebrospinal fluid (CSF) volumes than noncarriers but smaller gray matter (GM) volumes. There was no significant difference in white matter (WM) and total brain parenchymal (TBP) volumes between APOE ε4 carriers and noncarriers. Tests for linear trend showed that individuals with lower leisure activity levels had greater WMH and CSF volumes, smaller TBP, WM and GM volumes than those with the highest levels of participation. The significant positive trend of the leisure activity with the brain tissue volumes was observed in the APOE ε4 carriers as well as in noncarriers after adjustment for demographic and health factors. These cross-sectional data suggest leisure activity is associated with tissue volumes in the brain irrespective of the APOE ε4 risk allele status.

Original language	English
Pages (from-to)	829.e1-829.e8
Journal	Neurobiology of Aging
Volume	33
Issue number	4
DOIs	https://doi.org/10.1016/j.neurobiolaging.2011.06.028
Publication status	Published - Apr 2012

Bibliographical note

Funding Information:
The Age, Gene/Environment Susceptibility-Reykjavik Study is funded by NIH contract N01-AG-12100 , the NIA Intramural Research Program, Hjartavernd (the Icelandic Heart Association), and Althingi (the Icelandic Parliament).

Other keywords

AGES-Reykjavik study
APOE
Brain volumes
Leisure activities
MRI

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10.1016/j.neurobiolaging.2011.06.028

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title = "Brain tissue volumes by APOE genotype and leisure activity-the AGES-Reykjavik Study",

abstract = "This study investigates the association of the APOE ε4 allele and leisure activity with brain tissue volumes, including white matter hyperintensities (WMH), in a population-based cohort of 4303 nondemented individuals, aged 66-96 years. APOE ε4 carriers were shown to have greater WMH and cerebrospinal fluid (CSF) volumes than noncarriers but smaller gray matter (GM) volumes. There was no significant difference in white matter (WM) and total brain parenchymal (TBP) volumes between APOE ε4 carriers and noncarriers. Tests for linear trend showed that individuals with lower leisure activity levels had greater WMH and CSF volumes, smaller TBP, WM and GM volumes than those with the highest levels of participation. The significant positive trend of the leisure activity with the brain tissue volumes was observed in the APOE ε4 carriers as well as in noncarriers after adjustment for demographic and health factors. These cross-sectional data suggest leisure activity is associated with tissue volumes in the brain irrespective of the APOE ε4 risk allele status.",

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author = "Hafsteinsdottir, {Sigridur Harpa} and Gudny Eiriksdottir and Sigurdur Sigurdsson and Thor Aspelund and Harris, {Tamara B.} and Launer, {Lenore J.} and Vilmundur Gudnason",

note = "Funding Information: The Age, Gene/Environment Susceptibility-Reykjavik Study is funded by NIH contract N01-AG-12100 , the NIA Intramural Research Program, Hjartavernd (the Icelandic Heart Association), and Althingi (the Icelandic Parliament).",

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doi = "10.1016/j.neurobiolaging.2011.06.028",

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AU - Aspelund, Thor

AU - Harris, Tamara B.

AU - Launer, Lenore J.

AU - Gudnason, Vilmundur

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Brain tissue volumes by APOE genotype and leisure activity-the AGES-Reykjavik Study

Abstract

Bibliographical note

Other keywords

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