Bone tumours in European children and adolescents, 1978-1997. Report from the Automated Childhood Cancer Information System project

C. A. Stiller*, S. S. Bielack, G. Jundt, E. Steliarova-Foucher, S. V. Petrovich, O. Budanov, H. Storm, N. Christensen, T. Aareleid, T. Hakulinen, R. Sankila, E. Pukkala, E. Le Gall, I. Tron, B. Lacour, E. Desandes, J. L. Bernard, P. Pillon, J. C. Gentet, F. FreyconC. Berger, L. Remontet, A. Danzon, M. Mercier, J. P. Daurès, B. Tretarre, F. Ménégoz, A. V. Guizard, M. Velten, A. Buemi, N. Raverdy, M. Sauvage, P. Grosclaude, P. Kaatsch, B. Eisinger, R. Stabenow, D. Schuler, Z. Jakab, G. Borgulya, L. Tryggvadottir, J. G. Jonasson, K. Bjarnadottir, H. Comber, F. Dwane, C. Magnani, G. Pastore, F. Pannelli, C. Pascucci, S. Ferretti, E. Conti, V. Ramazzotti, M. C. Cercato, M. Vercelli, A. Puppo, P. Crosignani, G. Tagliabue, A. Tittarelli, V. De Lisi, P. Sgargi, R. Zanetti, S. Patriarca, R. Tumino, M. Budroni, D. Piras, E. Paci, E. Crocetti, F. La Rosa, F. Stracci, P. Zambon, S. Guzzinati, M. Dalmas, J. W.W. Coebergh, J. van Dijck, A. Wit, F. Langmark, A. Johansen, A. Andersen, I. Plesko, M. Primic Z? akelj, V. Pompe-Kirn, R. Peris-Bonet, B. Giner, E. Almar Marques, A. Mateos Ramos, J. Ramon Quiros Garcia, A. Can˜ ada Martínez, I. Izarzugaza, A. Alemán Herrera, P. Viladiu, R. Marcos, A. Izquierdo, C. Martínez Garcia, A. Obrador, I. Garau, E. Ardanaz, J. Borràs, J. Galceran, J. de la Bárcena Guallar, M. C. Martos Jiménez, C. Bouchardy, M. Usel, J. Allemann, H. Frick, T. Fisch, S. Ess, F. Joris, D. de Weck, S. Yalcin Eser, M. F.G. Murphy, G. J. Draper, A. Gavin, C. Fox, W. Hamill, R. Middleton, D. Brewster, L. Bhatti, A. McDonald

*Corresponding author for this work

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176 Citations (Scopus)

Abstract

Data on 5572 children and adolescents diagnosed with malignant bone tumours (International Classification of Childhood Cancer, Group VIII) before the age of 20 years during 1978-1997 in Europe were extracted from the Automated Childhood Cancer Information System (ACCIS) database. Age-standardised incidence among children during the period 1988-1997 was similar for boys and girls aged 0-14 years (5.5-5.6 per million). Among adolescents aged 15-19 years, males had higher incidence (19.3 per million) than females (10.7 per million). Among children, osteosarcoma accounted for 51% of registrations and Ewing's sarcoma for 41%. Among adolescents, 55% of registrations were osteosarcoma and 28% Ewing's sarcoma. Both tumours had their highest incidence in late childhood or early adolescence. There were no significant time trends in incidence during 1978-1997. Five-year survival estimates for patients diagnosed during 1988-1997 were, respectively, 59% and 51% among children and adolescents with osteosarcoma and 62% and 30% among children and adolescents with Ewing's sarcoma. Between 1978-1982 and 1993-1997, survival increased for both children and adolescents with osteosarcoma, and for children with Ewing's sarcoma.

Original languageEnglish
Pages (from-to)2124-2135
Number of pages12
JournalEuropean Journal of Cancer
Volume42
Issue number13
DOIs
Publication statusPublished - 1 Sept 2006

Bibliographical note

Funding Information:
The ACCIS project was funded by the European Commission from the ’Europe Against Cancer’ programme (1996–2002, contracts SI2.126875, SI2.321970 and SPC.2002303), jointly with the International Agency for Research on Cancer (IARC). Data analyses were partly funded by the French Ligue Nationale contre le Cancer, Comité du Rhône. The Childhood Cancer Research Group receives funding from the Department of Health and the Scottish Ministers. The views expressed in the publication are those of the authors and not necessarily those of the Department of Health and the Scottish Ministers.

Other keywords

  • Adolescent
  • Bone neoplasms
  • Childhood cancer
  • Epidemiology
  • Europe
  • Ewing's sarcoma
  • Incidence
  • Osteosarcoma
  • Registry
  • Survival

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