Body mass index and weight change are associated with adult lung function trajectories: the prospective ECRHS study

Gabriela P Peralta; Alessandro Marcon; Anne-Elie Carsin; Michael J Abramson; Simone Accordini; André FS Amaral; Josep M Antó; Gayan Bowatte; Peter Burney; Angelo Corsico; Pascal Demoly; Shyamali Dharmage; Bertil Forsberg; Elaine Fuertes; Vanessa Garcia-Larsen; Thorarinn Gislason; José-Antonio Gullón; Joachim Heinrich; Mathias Holm; Deborah L Jarvis; Christer Janson; Rain Jogi; Ane Johannessen; Bénédicte Leynaert; Jesús Martínez-Moratalla Rovira; Dennis Nowak; Nicole Probst-Hensch; Chantal Raherison; José-Luis Sánchez-Ramos; Torben Sigsgaard; Valérie Siroux; Giulia Squillacioti; Isabel Urrutia; Joost Weyler; Jan-Paul Zock; Judith Garcia-Aymerich

doi:10.1136/thoraxjnl-2019-213880

Body mass index and weight change are associated with adult lung function trajectories: the prospective ECRHS study

Gabriela P Peralta, Alessandro Marcon, Anne-Elie Carsin, Michael J Abramson, Simone Accordini, André FS Amaral, Josep M Antó, Gayan Bowatte, Peter Burney, Angelo Corsico, Pascal Demoly, Shyamali Dharmage, Bertil Forsberg, Elaine Fuertes, Vanessa Garcia-Larsen, Thorarinn Gislason, José-Antonio Gullón, Joachim Heinrich, Mathias Holm, Deborah L JarvisChrister Janson, Rain Jogi, Ane Johannessen, Bénédicte Leynaert, Jesús Martínez-Moratalla Rovira, Dennis Nowak, Nicole Probst-Hensch, Chantal Raherison, José-Luis Sánchez-Ramos, Torben Sigsgaard, Valérie Siroux, Giulia Squillacioti, Isabel Urrutia, Joost Weyler, Jan-Paul Zock, Judith Garcia-Aymerich

Research output: Contribution to journal › Article › peer-review

5 Citations (Scopus)

Abstract

Background: Previous studies have reported an association between weight increase and excess lung function decline in young adults followed for short periods. We aimed to estimate lung function trajectories during adulthood from 20-year weight change profiles using data from the population-based European Community Respiratory Health Survey (ECRHS). Methods: We included 3673 participants recruited at age 20-44 years with repeated measurements of weight and lung function (forced vital capacity (FVC), forced expiratory volume in 1 s (FEV 1)) in three study waves (1991-93, 1999-2003, 2010-14) until they were 39-67 years of age. We classified subjects into weight change profiles according to baseline body mass index (BMI) categories and weight change over 20 years. We estimated trajectories of lung function over time as a function of weight change profiles using population-averaged generalised estimating equations. Results: In individuals with normal BMI, overweight and obesity at baseline, moderate (0.25-1 kg/year) and high weight gain (>1 kg/year) during follow-up were associated with accelerated FVC and FEV 1 declines. Compared with participants with baseline normal BMI and stable weight (±0.25 kg/year), obese individuals with high weight gain during follow-up had -1011 mL (95% CI -1.259 to -763) lower estimated FVC at 65 years despite similar estimated FVC levels at 25 years. Obese individuals at baseline who lost weight (<-0.25 kg/year) exhibited an attenuation of FVC and FEV 1 declines. We found no association between weight change profiles and FEV 1 /FVC decline. Conclusion: Moderate and high weight gain over 20 years was associated with accelerated lung function decline, while weight loss was related to its attenuation. Control of weight gain is important for maintaining good lung function in adult life.

Original language	English
Pages (from-to)	313-320
Journal	Thorax
Volume	75
Issue number	4
DOIs	https://doi.org/10.1136/thoraxjnl-2019-213880
Publication status	Published - 25 Feb 2020

Other keywords

Adults
BMI
Epidemiology
Lung function
Obesity
Weight change
Lungu
Offita
Þyngd
LUNGNA
Líkamsþyngdarstuðull
Lungnasjúkdómar
Body Weight Changes
Body Weight
Respiratory Function Tests

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10.1136/thoraxjnl-2019-213880

Cite this

Peralta, G. P., Marcon, A., Carsin, A.-E., Abramson, M. J., Accordini, S., Amaral, A. FS., Antó, J. M., Bowatte, G., Burney, P., Corsico, A., Demoly, P., Dharmage, S., Forsberg, B., Fuertes, E., Garcia-Larsen, V., Gislason, T., Gullón, J.-A., Heinrich, J., Holm, M., ... Garcia-Aymerich, J. (2020). Body mass index and weight change are associated with adult lung function trajectories: the prospective ECRHS study. Thorax, 75(4), 313-320. https://doi.org/10.1136/thoraxjnl-2019-213880

@article{ed6d071d724541f793af80eaab6d272b,

title = "Body mass index and weight change are associated with adult lung function trajectories: the prospective ECRHS study",

abstract = "Background: Previous studies have reported an association between weight increase and excess lung function decline in young adults followed for short periods. We aimed to estimate lung function trajectories during adulthood from 20-year weight change profiles using data from the population-based European Community Respiratory Health Survey (ECRHS). Methods: We included 3673 participants recruited at age 20-44 years with repeated measurements of weight and lung function (forced vital capacity (FVC), forced expiratory volume in 1 s (FEV 1)) in three study waves (1991-93, 1999-2003, 2010-14) until they were 39-67 years of age. We classified subjects into weight change profiles according to baseline body mass index (BMI) categories and weight change over 20 years. We estimated trajectories of lung function over time as a function of weight change profiles using population-averaged generalised estimating equations. Results: In individuals with normal BMI, overweight and obesity at baseline, moderate (0.25-1 kg/year) and high weight gain (>1 kg/year) during follow-up were associated with accelerated FVC and FEV 1 declines. Compared with participants with baseline normal BMI and stable weight (±0.25 kg/year), obese individuals with high weight gain during follow-up had -1011 mL (95% CI -1.259 to -763) lower estimated FVC at 65 years despite similar estimated FVC levels at 25 years. Obese individuals at baseline who lost weight (<-0.25 kg/year) exhibited an attenuation of FVC and FEV 1 declines. We found no association between weight change profiles and FEV 1 /FVC decline. Conclusion: Moderate and high weight gain over 20 years was associated with accelerated lung function decline, while weight loss was related to its attenuation. Control of weight gain is important for maintaining good lung function in adult life.",

keywords = "Adults, BMI, Epidemiology, Lung function, Obesity, Weight change, Lungu, Offita, {\TH}yngd, LUNGNA, L{\'i}kams{\th}yngdarstu{\dh}ull, Lungnasj{\'u}kd{\'o}mar, Body Weight Changes, Body Weight, Respiratory Function Tests, Adults, BMI, Epidemiology, Lung function, Obesity, Weight change, Lungu, Offita, {\TH}yngd, LUNGNA, L{\'i}kams{\th}yngdarstu{\dh}ull, Lungnasj{\'u}kd{\'o}mar, Body Weight Changes, Body Weight, Respiratory Function Tests",

author = "Peralta, {Gabriela P} and Alessandro Marcon and Anne-Elie Carsin and Abramson, {Michael J} and Simone Accordini and Amaral, {Andr{\'e} FS} and Ant{\'o}, {Josep M} and Gayan Bowatte and Peter Burney and Angelo Corsico and Pascal Demoly and Shyamali Dharmage and Bertil Forsberg and Elaine Fuertes and Vanessa Garcia-Larsen and Thorarinn Gislason and Jos{\'e}-Antonio Gull{\'o}n and Joachim Heinrich and Mathias Holm and Jarvis, {Deborah L} and Christer Janson and Rain Jogi and Ane Johannessen and B{\'e}n{\'e}dicte Leynaert and Rovira, {Jes{\'u}s Mart{\'i}nez-Moratalla} and Dennis Nowak and Nicole Probst-Hensch and Chantal Raherison and Jos{\'e}-Luis S{\'a}nchez-Ramos and Torben Sigsgaard and Val{\'e}rie Siroux and Giulia Squillacioti and Isabel Urrutia and Joost Weyler and Jan-Paul Zock and Judith Garcia-Aymerich",

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month = feb,

day = "25",

doi = "10.1136/thoraxjnl-2019-213880",

language = "English",

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pages = "313--320",

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Peralta, GP, Marcon, A, Carsin, A-E, Abramson, MJ, Accordini, S, Amaral, AFS, Antó, JM, Bowatte, G, Burney, P, Corsico, A, Demoly, P, Dharmage, S, Forsberg, B, Fuertes, E, Garcia-Larsen, V, Gislason, T, Gullón, J-A, Heinrich, J, Holm, M, Jarvis, DL, Janson, C, Jogi, R, Johannessen, A, Leynaert, B, Rovira, JM-M, Nowak, D, Probst-Hensch, N, Raherison, C, Sánchez-Ramos, J-L, Sigsgaard, T, Siroux, V, Squillacioti, G, Urrutia, I, Weyler, J, Zock, J-P & Garcia-Aymerich, J 2020, 'Body mass index and weight change are associated with adult lung function trajectories: the prospective ECRHS study', Thorax, vol. 75, no. 4, pp. 313-320. https://doi.org/10.1136/thoraxjnl-2019-213880

TY - JOUR

T1 - Body mass index and weight change are associated with adult lung function trajectories: the prospective ECRHS study

AU - Peralta, Gabriela P

AU - Marcon, Alessandro

AU - Carsin, Anne-Elie

AU - Abramson, Michael J

AU - Accordini, Simone

AU - Amaral, André FS

AU - Antó, Josep M

AU - Bowatte, Gayan

AU - Burney, Peter

AU - Corsico, Angelo

AU - Demoly, Pascal

AU - Dharmage, Shyamali

AU - Forsberg, Bertil

AU - Fuertes, Elaine

AU - Garcia-Larsen, Vanessa

AU - Gislason, Thorarinn

AU - Gullón, José-Antonio

AU - Heinrich, Joachim

AU - Holm, Mathias

AU - Jarvis, Deborah L

AU - Janson, Christer

AU - Jogi, Rain

AU - Johannessen, Ane

AU - Leynaert, Bénédicte

AU - Rovira, Jesús Martínez-Moratalla

AU - Nowak, Dennis

AU - Probst-Hensch, Nicole

AU - Raherison, Chantal

AU - Sánchez-Ramos, José-Luis

AU - Sigsgaard, Torben

AU - Siroux, Valérie

AU - Squillacioti, Giulia

AU - Urrutia, Isabel

AU - Weyler, Joost

AU - Zock, Jan-Paul

AU - Garcia-Aymerich, Judith

PY - 2020/2/25

Y1 - 2020/2/25

N2 - Background: Previous studies have reported an association between weight increase and excess lung function decline in young adults followed for short periods. We aimed to estimate lung function trajectories during adulthood from 20-year weight change profiles using data from the population-based European Community Respiratory Health Survey (ECRHS). Methods: We included 3673 participants recruited at age 20-44 years with repeated measurements of weight and lung function (forced vital capacity (FVC), forced expiratory volume in 1 s (FEV 1)) in three study waves (1991-93, 1999-2003, 2010-14) until they were 39-67 years of age. We classified subjects into weight change profiles according to baseline body mass index (BMI) categories and weight change over 20 years. We estimated trajectories of lung function over time as a function of weight change profiles using population-averaged generalised estimating equations. Results: In individuals with normal BMI, overweight and obesity at baseline, moderate (0.25-1 kg/year) and high weight gain (>1 kg/year) during follow-up were associated with accelerated FVC and FEV 1 declines. Compared with participants with baseline normal BMI and stable weight (±0.25 kg/year), obese individuals with high weight gain during follow-up had -1011 mL (95% CI -1.259 to -763) lower estimated FVC at 65 years despite similar estimated FVC levels at 25 years. Obese individuals at baseline who lost weight (<-0.25 kg/year) exhibited an attenuation of FVC and FEV 1 declines. We found no association between weight change profiles and FEV 1 /FVC decline. Conclusion: Moderate and high weight gain over 20 years was associated with accelerated lung function decline, while weight loss was related to its attenuation. Control of weight gain is important for maintaining good lung function in adult life.

AB - Background: Previous studies have reported an association between weight increase and excess lung function decline in young adults followed for short periods. We aimed to estimate lung function trajectories during adulthood from 20-year weight change profiles using data from the population-based European Community Respiratory Health Survey (ECRHS). Methods: We included 3673 participants recruited at age 20-44 years with repeated measurements of weight and lung function (forced vital capacity (FVC), forced expiratory volume in 1 s (FEV 1)) in three study waves (1991-93, 1999-2003, 2010-14) until they were 39-67 years of age. We classified subjects into weight change profiles according to baseline body mass index (BMI) categories and weight change over 20 years. We estimated trajectories of lung function over time as a function of weight change profiles using population-averaged generalised estimating equations. Results: In individuals with normal BMI, overweight and obesity at baseline, moderate (0.25-1 kg/year) and high weight gain (>1 kg/year) during follow-up were associated with accelerated FVC and FEV 1 declines. Compared with participants with baseline normal BMI and stable weight (±0.25 kg/year), obese individuals with high weight gain during follow-up had -1011 mL (95% CI -1.259 to -763) lower estimated FVC at 65 years despite similar estimated FVC levels at 25 years. Obese individuals at baseline who lost weight (<-0.25 kg/year) exhibited an attenuation of FVC and FEV 1 declines. We found no association between weight change profiles and FEV 1 /FVC decline. Conclusion: Moderate and high weight gain over 20 years was associated with accelerated lung function decline, while weight loss was related to its attenuation. Control of weight gain is important for maintaining good lung function in adult life.

KW - Adults

KW - BMI

KW - Epidemiology

KW - Lung function

KW - Obesity

KW - Weight change

KW - Lungu

KW - Offita

KW - Þyngd

KW - LUNGNA

KW - Líkamsþyngdarstuðull

KW - Lungnasjúkdómar

KW - Body Weight Changes

KW - Body Weight

KW - Respiratory Function Tests

KW - Adults

KW - BMI

KW - Epidemiology

KW - Lung function

KW - Obesity

KW - Weight change

KW - Lungu

KW - Offita

KW - Þyngd

KW - LUNGNA

KW - Líkamsþyngdarstuðull

KW - Lungnasjúkdómar

KW - Body Weight Changes

KW - Body Weight

KW - Respiratory Function Tests

U2 - 10.1136/thoraxjnl-2019-213880

DO - 10.1136/thoraxjnl-2019-213880

M3 - Article

C2 - 32098862

SN - 0040-6376

VL - 75

SP - 313

EP - 320

JO - Thorax

JF - Thorax

IS - 4

ER -

Body mass index and weight change are associated with adult lung function trajectories: the prospective ECRHS study

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