Biobank-driven genomic discovery yields new insight into atrial fibrillation biology.

Jonas B Nielsen; Rosa B Thorolfsdottir; Lars G Fritsche; Wei Zhou; Morten W Skov; Sarah E Graham; Todd J Herron; Shane McCarthy; Ellen M Schmidt; Gardar Sveinbjornsson; Ida Surakka; Michael R Mathis; Masatoshi Yamazaki; Ryan D Crawford; Maiken E Gabrielsen; Anne Heidi Skogholt; Oddgeir L Holmen; Maoxuan Lin; Brooke N Wolford; Rounak Dey; Håvard Dalen; Patrick Sulem; Jonathan H Chung; Joshua D Backman; David O Arnar; Unnur Thorsteinsdottir; Aris Baras; Colm O'Dushlaine; Anders G Holst; Xiaoquan Wen; Whitney Hornsby; Frederick E Dewey; Michael Boehnke; Sachin Kheterpal; Bhramar Mukherjee; Seunggeun Lee; Hyun M Kang; Hilma Holm; Jacob Kitzman; Jordan A Shavit; José Jalife; Chad M Brummett; Tanya M Teslovich; David J Carey; Daniel F Gudbjartsson; Kari Stefansson; Gonçalo R Abecasis; Kristian Hveem; Cristen J Willer

doi:10.1038/s41588-018-0171-3

Biobank-driven genomic discovery yields new insight into atrial fibrillation biology.

Jonas B Nielsen, Rosa B Thorolfsdottir, Lars G Fritsche, Wei Zhou, Morten W Skov, Sarah E Graham, Todd J Herron, Shane McCarthy, Ellen M Schmidt, Gardar Sveinbjornsson, Ida Surakka, Michael R Mathis, Masatoshi Yamazaki, Ryan D Crawford, Maiken E Gabrielsen, Anne Heidi Skogholt, Oddgeir L Holmen, Maoxuan Lin, Brooke N Wolford, Rounak DeyHåvard Dalen, Patrick Sulem, Jonathan H Chung, Joshua D Backman, David O Arnar, Unnur Thorsteinsdottir, Aris Baras, Colm O'Dushlaine, Anders G Holst, Xiaoquan Wen, Whitney Hornsby, Frederick E Dewey, Michael Boehnke, Sachin Kheterpal, Bhramar Mukherjee, Seunggeun Lee, Hyun M Kang, Hilma Holm, Jacob Kitzman, Jordan A Shavit, José Jalife, Chad M Brummett, Tanya M Teslovich, David J Carey, Daniel F Gudbjartsson, Kari Stefansson, Gonçalo R Abecasis, Kristian Hveem, Cristen J Willer

Research output: Contribution to journal › Article › peer-review

Abstract

To identify genetic variation underlying atrial fibrillation, the most common cardiac arrhythmia, we performed a genome-wide association study of >1,000,000 people, including 60,620 atrial fibrillation cases and 970,216 controls. We identified 142 independent risk variants at 111 loci and prioritized 151 functional candidate genes likely to be involved in atrial fibrillation. Many of the identified risk variants fall near genes where more deleterious mutations have been reported to cause serious heart defects in humans (GATA4, MYH6, NKX2-5, PITX2, TBX5)

Original language	English
Journal	Nature Genetics
DOIs	https://doi.org/10.1038/s41588-018-0171-3
Publication status	Published - 1 Sept 2018

Other keywords

Gáttatif
Gen
Atrial Fibrillation
Genetics

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10.1038/s41588-018-0171-3

https://www.nature.com/articles/s41588-018-0171-3

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Nielsen, J. B., Thorolfsdottir, R. B., Fritsche, L. G., Zhou, W., Skov, M. W., Graham, S. E., Herron, T. J., McCarthy, S., Schmidt, E. M., Sveinbjornsson, G., Surakka, I., Mathis, M. R., Yamazaki, M., Crawford, R. D., Gabrielsen, M. E., Skogholt, A. H., Holmen, O. L., Lin, M., Wolford, B. N., ... Willer, C. J. (2018). Biobank-driven genomic discovery yields new insight into atrial fibrillation biology. Nature Genetics. https://doi.org/10.1038/s41588-018-0171-3

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abstract = "To identify genetic variation underlying atrial fibrillation, the most common cardiac arrhythmia, we performed a genome-wide association study of >1,000,000 people, including 60,620 atrial fibrillation cases and 970,216 controls. We identified 142 independent risk variants at 111 loci and prioritized 151 functional candidate genes likely to be involved in atrial fibrillation. Many of the identified risk variants fall near genes where more deleterious mutations have been reported to cause serious heart defects in humans (GATA4, MYH6, NKX2-5, PITX2, TBX5)",

keywords = "G{\'a}ttatif, Gen, Atrial Fibrillation, Genetics, G{\'a}ttatif, Gen, Atrial Fibrillation, Genetics",

author = "Nielsen, {Jonas B} and Thorolfsdottir, {Rosa B} and Fritsche, {Lars G} and Wei Zhou and Skov, {Morten W} and Graham, {Sarah E} and Herron, {Todd J} and Shane McCarthy and Schmidt, {Ellen M} and Gardar Sveinbjornsson and Ida Surakka and Mathis, {Michael R} and Masatoshi Yamazaki and Crawford, {Ryan D} and Gabrielsen, {Maiken E} and Skogholt, {Anne Heidi} and Holmen, {Oddgeir L} and Maoxuan Lin and Wolford, {Brooke N} and Rounak Dey and H{\aa}vard Dalen and Patrick Sulem and Chung, {Jonathan H} and Backman, {Joshua D} and Arnar, {David O} and Unnur Thorsteinsdottir and Aris Baras and Colm O'Dushlaine and Holst, {Anders G} and Xiaoquan Wen and Whitney Hornsby and Dewey, {Frederick E} and Michael Boehnke and Sachin Kheterpal and Bhramar Mukherjee and Seunggeun Lee and Kang, {Hyun M} and Hilma Holm and Jacob Kitzman and Shavit, {Jordan A} and Jos{\'e} Jalife and Brummett, {Chad M} and Teslovich, {Tanya M} and Carey, {David J} and Gudbjartsson, {Daniel F} and Kari Stefansson and Abecasis, {Gon{\c c}alo R} and Kristian Hveem and Willer, {Cristen J}",

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doi = "10.1038/s41588-018-0171-3",

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Nielsen, JB, Thorolfsdottir, RB, Fritsche, LG, Zhou, W, Skov, MW, Graham, SE, Herron, TJ, McCarthy, S, Schmidt, EM, Sveinbjornsson, G, Surakka, I, Mathis, MR, Yamazaki, M, Crawford, RD, Gabrielsen, ME, Skogholt, AH, Holmen, OL, Lin, M, Wolford, BN, Dey, R, Dalen, H, Sulem, P, Chung, JH, Backman, JD, Arnar, DO , Thorsteinsdottir, U, Baras, A, O'Dushlaine, C, Holst, AG, Wen, X, Hornsby, W, Dewey, FE, Boehnke, M, Kheterpal, S, Mukherjee, B, Lee, S, Kang, HM, Holm, H, Kitzman, J, Shavit, JA, Jalife, J, Brummett, CM, Teslovich, TM, Carey, DJ, Gudbjartsson, DF, Stefansson, K, Abecasis, GR, Hveem, K & Willer, CJ 2018, 'Biobank-driven genomic discovery yields new insight into atrial fibrillation biology.', Nature Genetics. https://doi.org/10.1038/s41588-018-0171-3

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T1 - Biobank-driven genomic discovery yields new insight into atrial fibrillation biology.

AU - Nielsen, Jonas B

AU - Thorolfsdottir, Rosa B

AU - Fritsche, Lars G

AU - Zhou, Wei

AU - Skov, Morten W

AU - Graham, Sarah E

AU - Herron, Todd J

AU - McCarthy, Shane

AU - Schmidt, Ellen M

AU - Sveinbjornsson, Gardar

AU - Surakka, Ida

AU - Mathis, Michael R

AU - Yamazaki, Masatoshi

AU - Crawford, Ryan D

AU - Gabrielsen, Maiken E

AU - Skogholt, Anne Heidi

AU - Holmen, Oddgeir L

AU - Lin, Maoxuan

AU - Wolford, Brooke N

AU - Dey, Rounak

AU - Dalen, Håvard

AU - Sulem, Patrick

AU - Chung, Jonathan H

AU - Backman, Joshua D

AU - Arnar, David O

AU - Thorsteinsdottir, Unnur

AU - Baras, Aris

AU - O'Dushlaine, Colm

AU - Holst, Anders G

AU - Wen, Xiaoquan

AU - Hornsby, Whitney

AU - Dewey, Frederick E

AU - Boehnke, Michael

AU - Kheterpal, Sachin

AU - Mukherjee, Bhramar

AU - Lee, Seunggeun

AU - Kang, Hyun M

AU - Holm, Hilma

AU - Kitzman, Jacob

AU - Shavit, Jordan A

AU - Jalife, José

AU - Brummett, Chad M

AU - Teslovich, Tanya M

AU - Carey, David J

AU - Gudbjartsson, Daniel F

AU - Stefansson, Kari

AU - Abecasis, Gonçalo R

AU - Hveem, Kristian

AU - Willer, Cristen J

PY - 2018/9/1

Y1 - 2018/9/1

N2 - To identify genetic variation underlying atrial fibrillation, the most common cardiac arrhythmia, we performed a genome-wide association study of >1,000,000 people, including 60,620 atrial fibrillation cases and 970,216 controls. We identified 142 independent risk variants at 111 loci and prioritized 151 functional candidate genes likely to be involved in atrial fibrillation. Many of the identified risk variants fall near genes where more deleterious mutations have been reported to cause serious heart defects in humans (GATA4, MYH6, NKX2-5, PITX2, TBX5)

AB - To identify genetic variation underlying atrial fibrillation, the most common cardiac arrhythmia, we performed a genome-wide association study of >1,000,000 people, including 60,620 atrial fibrillation cases and 970,216 controls. We identified 142 independent risk variants at 111 loci and prioritized 151 functional candidate genes likely to be involved in atrial fibrillation. Many of the identified risk variants fall near genes where more deleterious mutations have been reported to cause serious heart defects in humans (GATA4, MYH6, NKX2-5, PITX2, TBX5)

KW - Gáttatif

KW - Gen

KW - Atrial Fibrillation

KW - Genetics

KW - Gáttatif

KW - Gen

KW - Atrial Fibrillation

KW - Genetics

U2 - 10.1038/s41588-018-0171-3

DO - 10.1038/s41588-018-0171-3

M3 - Article

C2 - 30061737

SN - 1546-1718

JO - Nature Genetics

JF - Nature Genetics

ER -

Biobank-driven genomic discovery yields new insight into atrial fibrillation biology.

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