bcTol: a highly water-soluble biradical for efficient dynamic nuclear polarization of biomolecules

Anil P. Jagtap, Michel-Andreas Geiger, Daniel Stöppler, Marcella Orwick-Rydmark, Hartmut Oschkinat, Snorri Sigurdsson

Research output: Contribution to journalArticlepeer-review

30 Citations (Scopus)

Abstract

Dynamic nuclear polarization (DNP) is an efficient method to overcome the inherent low sensitivity of magic-angle spinning (MAS) solid-state NMR. We report a new polarizing agent (bcTol), designed for biological applications, that yielded an enhancement value of 244 in a microcrystalline SH3 domain sample at 110 K.
Original languageEnglish
Pages (from-to)7020-7023
JournalChemical Communications
Volume52
Issue number43
DOIs
Publication statusPublished - 2016

Other keywords

  • Angle spinning NMR
  • Solid state
  • Nitroxide biradicals
  • Magnetic resonance
  • Amyloid fibrils
  • Protein
  • Resolution
  • Spectroscopy
  • Agents
  • Litrófsgreining
  • Segulmagn
  • Prótín
  • Kjarnsýrur

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