Association of morbus ledderhose with dupuytren's contracture

Kristján G. Gudmundsson*, Thorbjörn Jónsson, Reynir Arngrímsson

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

14 Citations (Scopus)


Background: Fibromatous nodules in the sole of the foot are often called Ledderhose disease. It is a benign nodular formation in the plantar aponeurosis, typically at the distal medial border. A lump forms and it can be a few centimeters in diameter. It is frequently seen as an isolated disease, but a relationship to Dupuytren's has been noted in some patients. Methods: The study was a part of a large cohort study, the Reykjavík study. Men with Dupuytren's disease (n = 122) were invited to follow-up 18 years after the initial observation. An equal number of controls, matched for age and smoking habits, were also invited. A total of 92 Dupuytren's patients and 101 control subjects attended for follow-up and were examined for plantar nodules. Statistical evaluation was carried out using chi-square test and presented as odds ratio (OR) and 95% confidence interval (95% CI). Results: Ledderhose disease was identified in 14 of the 92 (15.2%) men with Dupuytren's disease, while it was only in 4 of the 101 (3.9%) matched controls (OR = 4.35, 95% CI, 1.3-16.7, P < 0.01). Men operated for Dupuytren's disease or with finger contractures were more likely to have plantar nodules than those with only nodules or strings in the palms (OR = 6.1, 95% CI, 1.8-27.1, P < 0.001). The plantar involvement was related to family history of Dupuytren's disease (OR = 3.1, 95% CI, 1.1-8.5, P = 0.02). Conclusion: Men with manifestations of finger contractures or who need surgery for Dupuytren's disease are more likely to also develop plantar fibromas.

Original languageEnglish
Pages (from-to)841-845
Number of pages5
JournalFoot and Ankle International
Issue number6
Publication statusPublished - Jun 2013

Bibliographical note

Funding Information:
The author(s) declared receipt of the following financial support for the research, authorship, and/or publication of this article: The study was supported by research grants from the Icelandic Centre for Research and the Science Fund of Family Physicians in Iceland.

Other keywords

  • Dupuytren's disease
  • Epidemiology
  • Ledderhose disease
  • Plantar fascia
  • Plantar fibromatosis


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