TY - JOUR
T1 - Association of HLA-DRB1*01 with Dupuytren's disease
AU - Jónsson, T.
AU - Gudmundsson, K. G.
AU - Bjarnadóttir, K.
AU - Hjálmarsdótti, Í B.
AU - Gudmundsson, S.
AU - Arngrímsson, R.
PY - 2013
Y1 - 2013
N2 - Objectives: To explore the human leucocyte antigen (HLA)-DRB1 allele frequency in Dupuytren's disease (DD). Method: HLA-DRB1 genotypes were analysed by sequence-specific primers (SSPs) in samples collected from 172 men participating in a nested case-control study on the clinical manifestations and progression of DD. Of those, 121 had signs of DD while 51 did not. Of the 121 men with DD, 49 had contracted fingers or had been operated on, while 72 had nodules or fibrous cords in the palms. Odds ratios (ORs) and 95% confidence interval (CIs) were used to evaluate the results. Results: The HLA-DRB1*01 allele was observed in 26 of the 121 affected men (23.7%) but in only four of the controls (7.8%) (OR 3.22, 95% CI 1.06-9.75). The HLA-DRB1*01 allele frequency in those affected was 11%, while in the control group it was 4% (OR 3.07, 95% CI 1.05-9.03). Conclusions: This observation indicates a possible association of HLA-DRB1*01 with DD, but further studies are needed for confirmation.
AB - Objectives: To explore the human leucocyte antigen (HLA)-DRB1 allele frequency in Dupuytren's disease (DD). Method: HLA-DRB1 genotypes were analysed by sequence-specific primers (SSPs) in samples collected from 172 men participating in a nested case-control study on the clinical manifestations and progression of DD. Of those, 121 had signs of DD while 51 did not. Of the 121 men with DD, 49 had contracted fingers or had been operated on, while 72 had nodules or fibrous cords in the palms. Odds ratios (ORs) and 95% confidence interval (CIs) were used to evaluate the results. Results: The HLA-DRB1*01 allele was observed in 26 of the 121 affected men (23.7%) but in only four of the controls (7.8%) (OR 3.22, 95% CI 1.06-9.75). The HLA-DRB1*01 allele frequency in those affected was 11%, while in the control group it was 4% (OR 3.07, 95% CI 1.05-9.03). Conclusions: This observation indicates a possible association of HLA-DRB1*01 with DD, but further studies are needed for confirmation.
UR - http://www.scopus.com/inward/record.url?scp=84872841670&partnerID=8YFLogxK
U2 - 10.3109/03009742.2012.713982
DO - 10.3109/03009742.2012.713982
M3 - Article
C2 - 22991974
AN - SCOPUS:84872841670
SN - 0300-9742
VL - 42
SP - 45
EP - 47
JO - Scandinavian Journal of Rheumatology
JF - Scandinavian Journal of Rheumatology
IS - 1
ER -