Assessment of budesonide patch tests

Bolli Bjarnason*, Ellen Flosadóttir, Torkel Fischer

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

19 Citations (Scopus)

Abstract

Patch-test technique for budesonide needs improvement. 20 subjects with positive or questionable patch-test responses to budesonide were retested for 3 to 96 h (4 days [D]) with polyester patches coated with budesonide in serial doses (150 to 0.074 μg/cm2). Multiple readings were taken visually and with a laser Doppler perfusion imaging technique up to 264 h (day [D]11). Additionally, all subjects were tested with 0.1% budesonide in petrolatum in Finn Chambers® for 48 h (2D) with readings taken at 72 (D3), 96 (D4) and 168 h (D7). Different dose levels and application times affected unpredictably highest assessments of reactions. No clear suppression of reactivity was observed at high doses. Time points of highest assessments of reactions varied between subjects but were generally the same for each subject with both reading methods regardless of dose levels or application times. Positive and negative subjects during the study were easily distinguished with all serial doses, regardless of assessment technique. At 2.0 μg/cm2, the lowest dose level tested on all subjects, longer applications than 24 h (1D) were required to detect all positive subjects. 48-h (2-D) applications required 2 readings, optimally at 96 (D4) and 216 h (D9). The only test technique with Finn Chambers® used here did not make such distinction possible.

Original languageEnglish
Pages (from-to)211-217
Number of pages7
JournalContact Dermatitis
Volume41
Issue number4
DOIs
Publication statusPublished - 1999

Other keywords

  • Allergic contact dermatitis
  • Bioengineering methods
  • Budesonide
  • Corticosteroids
  • Immunosuppression
  • Laser Doppler imaging
  • Patch testing technique
  • Skin perfusion

Fingerprint

Dive into the research topics of 'Assessment of budesonide patch tests'. Together they form a unique fingerprint.

Cite this