Assessment of balsam of Peru patch tests

Bolli Bjarnason*, Ellen Flosadóttir, Torkel Fischer

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

1 Citation (Scopus)

Abstract

To find an ideal test technique for as low a dose of balsam of Peru (Myroxylon Pereirae) as possible, subjects testing positive to balsam of Peru are re-tested with a 25% concentration of balsam of Peru in petrolatum. Applications are with Finn Chambers® for 6 different application times, and directly by foils for 96 h (4 days (D)). The goals are to confirm which subjects are positive and which are not, and, using that information, to see if it is possible to distinguish between these 2 groups, tested concomitantly at much lower serial dose levels, in terms of perfusion or by visual assessments. 5 different serial doses are applied with strips for 3-96 h (4D) and with foils for 96 h (4D). The Finn Chamber® tests allow a distinction between visually positive and negative subjects supported by perfusion assessments. With the foils, a 24X lower serial dose level than with the 25% test substance is sufficient to distinguish between positive and negative subjects in terms of perfusion values. This approach requires readings up to 9 days. With this test, the visual approach yields only 3 of 10 positive subjects. This study demonstrates that a lower test dose is possible with perfusion assessments compared to visual ones.

Original languageEnglish
Pages (from-to)326-329
Number of pages4
JournalContact Dermatitis
Volume42
Issue number6
DOIs
Publication statusPublished - 2000

Other keywords

  • Application time
  • Balsam of Peru
  • Bioengineering methods
  • Dose level
  • Laser Doppler perfusion imaging
  • Myroxylon Pereirae
  • Reading time
  • Sensitivity
  • Specificity
  • Test procedure
  • Test technique

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