Antimycobacterial activity of lichen metabolites in vitro

Kristín Ingólfsdóttir; Gavin A.C. Chung; Vilhjálmur G. Skúlason; Stefán R. Gissurarson; Margrét Vilhelmsdóttir

doi:10.1016/S0928-0987(97)00078-X

Antimycobacterial activity of lichen metabolites in vitro

Kristín Ingólfsdóttir^*, Gavin A.C. Chung, Vilhjálmur G. Skúlason, Stefán R. Gissurarson, Margrét Vilhelmsdóttir

^*Corresponding author for this work

Faculty of Pharmaceutical Sciences

Research output: Contribution to journal › Article › peer-review

162 Citations (Scopus)

Abstract

Several compounds, whose structures represent the most common chemical classes of lichen metabolites, were screened for in vitro activity against Mycobacterium aurum, a non-pathogenic organism with a similar sensitivity profile to M. tuberculosis. Of the compounds tested, usnic acid from Cladonia arbuscula exhibited the highest activity with an MIC value of 32 μg/ml. Atranorin and lobaric acid, both isolated from Stereocaulon alpinum, salazinic acid from Parmelia saxatilis and protolichesterinic acid from Cetraria islandica all showed MIC values ≤125 μg/ml.

Original language	English
Pages (from-to)	141-144
Number of pages	4
Journal	European Journal of Pharmaceutical Sciences
Volume	6
Issue number	2
DOIs	https://doi.org/10.1016/S0928-0987(97)00078-X
Publication status	Published - 1 Apr 1998

Bibliographical note

Funding Information:
The work was in part supported by the Icelandic Council of Science and the University of Iceland Research Fund. We thank Dr. Hordur Kristinsson for identification of the plant material and Dr. Sigrı́dur Jónsdóttir (Science Institute, University of Iceland) for recording 1 H and 13 C NMR data for usnic and salazinic acids.

Other keywords

Antimycobacterial
Atranorin
Lichen
Lobaric acid
Protolichesterinic acid
Salazinic acid
Usnic acid

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10.1016/S0928-0987(97)00078-X

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title = "Antimycobacterial activity of lichen metabolites in vitro",

abstract = "Several compounds, whose structures represent the most common chemical classes of lichen metabolites, were screened for in vitro activity against Mycobacterium aurum, a non-pathogenic organism with a similar sensitivity profile to M. tuberculosis. Of the compounds tested, usnic acid from Cladonia arbuscula exhibited the highest activity with an MIC value of 32 μg/ml. Atranorin and lobaric acid, both isolated from Stereocaulon alpinum, salazinic acid from Parmelia saxatilis and protolichesterinic acid from Cetraria islandica all showed MIC values ≤125 μg/ml.",

keywords = "Antimycobacterial, Atranorin, Lichen, Lobaric acid, Protolichesterinic acid, Salazinic acid, Usnic acid",

author = "Krist{\'i}n Ing{\'o}lfsd{\'o}ttir and Chung, {Gavin A.C.} and Sk{\'u}lason, {Vilhj{\'a}lmur G.} and Gissurarson, {Stef{\'a}n R.} and Margr{\'e}t Vilhelmsd{\'o}ttir",

note = "Funding Information: The work was in part supported by the Icelandic Council of Science and the University of Iceland Research Fund. We thank Dr. Hordur Kristinsson for identification of the plant material and Dr. Sigr{\'ı}dur J{\'o}nsd{\'o}ttir (Science Institute, University of Iceland) for recording 1 H and 13 C NMR data for usnic and salazinic acids. ",

year = "1998",

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doi = "10.1016/S0928-0987(97)00078-X",

language = "English",

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T1 - Antimycobacterial activity of lichen metabolites in vitro

AU - Ingólfsdóttir, Kristín

AU - Chung, Gavin A.C.

AU - Skúlason, Vilhjálmur G.

AU - Gissurarson, Stefán R.

AU - Vilhelmsdóttir, Margrét

N1 - Funding Information: The work was in part supported by the Icelandic Council of Science and the University of Iceland Research Fund. We thank Dr. Hordur Kristinsson for identification of the plant material and Dr. Sigrı́dur Jónsdóttir (Science Institute, University of Iceland) for recording 1 H and 13 C NMR data for usnic and salazinic acids.

PY - 1998/4/1

Y1 - 1998/4/1

N2 - Several compounds, whose structures represent the most common chemical classes of lichen metabolites, were screened for in vitro activity against Mycobacterium aurum, a non-pathogenic organism with a similar sensitivity profile to M. tuberculosis. Of the compounds tested, usnic acid from Cladonia arbuscula exhibited the highest activity with an MIC value of 32 μg/ml. Atranorin and lobaric acid, both isolated from Stereocaulon alpinum, salazinic acid from Parmelia saxatilis and protolichesterinic acid from Cetraria islandica all showed MIC values ≤125 μg/ml.

AB - Several compounds, whose structures represent the most common chemical classes of lichen metabolites, were screened for in vitro activity against Mycobacterium aurum, a non-pathogenic organism with a similar sensitivity profile to M. tuberculosis. Of the compounds tested, usnic acid from Cladonia arbuscula exhibited the highest activity with an MIC value of 32 μg/ml. Atranorin and lobaric acid, both isolated from Stereocaulon alpinum, salazinic acid from Parmelia saxatilis and protolichesterinic acid from Cetraria islandica all showed MIC values ≤125 μg/ml.

KW - Antimycobacterial

KW - Atranorin

KW - Lichen

KW - Lobaric acid

KW - Protolichesterinic acid

KW - Salazinic acid

KW - Usnic acid

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U2 - 10.1016/S0928-0987(97)00078-X

DO - 10.1016/S0928-0987(97)00078-X

M3 - Article

C2 - 9795033

AN - SCOPUS:0032055873

SN - 0928-0987

VL - 6

SP - 141

EP - 144

JO - European Journal of Pharmaceutical Sciences

JF - European Journal of Pharmaceutical Sciences

IS - 2

ER -

Antimycobacterial activity of lichen metabolites in vitro

Abstract

Bibliographical note

Other keywords

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