Almost winning: Induced MEG theta power in insula and orbitofrontal cortex increases during gambling near-misses and is associated with BOLD signal and gambling severity

Simon Dymond*, Natalia S. Lawrence, Benjamin T. Dunkley, Kenneth S.L. Yuen, Elanor C. Hinton, Mark R. Dixon, W. Miles Cox, Alice E. Hoon, Anita Munnelly, Suresh D. Muthukumaraswamy, Krish D. Singh

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

42 Citations (Scopus)

Abstract

In slot machine gambling, the "near-miss effect" (when a losing display physically resembles an actual win display) has been implicated in pathological gambling (PG). Functional magnetic resonance imaging (fMRI) with PG and non-PG participants shows that near-misses recruit reward-related circuitry, but little is known about the temporal dynamics and oscillatory changes underlying near-misses. The present multi-modal imaging study investigated the near-miss effect by combining the spatial resolution of blood oxygen-level dependent (BOLD)-fMRI with the spatial and temporal resolution of magnetoencephalography (MEG) during a slot machine task in PG and non-PG groups. Given previous findings on outcome (win and near-miss) processing, functional overlap was hypothesized between induced changes in temporal oscillations and BOLD response to wins and near-misses in PG. We first validated our task in a sample of varying gambling severity using BOLD-fMRI and then compared PG and non-PG participants using MEG to investigate changes in induced oscillatory power associated with win and near-miss, relative to loss, outcomes. Across both modalities, near-misses recruited similar brain regions to wins, including right inferior frontal gyrus and insula. Using MEG, increased theta-band (4-7. Hz) oscillations to near-misses were observed in the insula and right orbitofrontal cortex (OFC). Furthermore, this theta-band activity was positively associated with gambling severity. These findings demonstrate that the near-miss effect in insula and OFC is associated with induced theta oscillations. The significance of these findings for theories of PG and the development of potential biomarkers and therapeutic targets is discussed.

Original languageEnglish
Pages (from-to)210-219
Number of pages10
JournalNeuroImage
Volume91
DOIs
Publication statusPublished - 1 May 2014

Bibliographical note

Funding Information:
This work was supported by a program grant from the Wales Institute of Cognitive Neuroscience ( WBCS047 ). Internal funding from the Department of Psychology, Swansea University and the School of Psychology, Cardiff University further supported the work, including data analysis and manuscript preparation. We are grateful to Carlo Lucignoli for technical assistance with the slot machine task and to Barnaby Dunn, Stephen Johnston, Frederick Verbruggen, and Robert Whelan for their helpful comments. Natalia S. Lawrence is now at University of Exeter; Benjamin Dunkley at The Hospital for Sick Children, Toronto; Kenneth Sung Lai Yuen at University Medical Center, Mainz; Alice E. Hoon at College of Medicine, Swansea University; Anita Munnelly at University College Dublin; and Elanor C. Hinton at University of Bristol.

Other keywords

  • FMRI
  • Gambling
  • Insula
  • MEG
  • Orbitofrontal cortex
  • Theta

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