Age related macular degeneration in monozygotic twins and their spouses in Iceland

Maria S. Gottfredsdottir, Thordur Sverrisson, David C. Musch, Einar Stefánsson*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

57 Citations (Scopus)

Abstract

Purpose: To examine the importance of genetic factors in age-related macular degeneration by using a twin study to compare the concordance of age-related macular degeneration in monozygotic twin pairs and their spouses. Methods: This was a prospective study that included 50 twin pairs and 47 spouses. Zygosity was determined by genetic laboratory testing. Macular findings were graded based on the grading system used by the Macular Photocoagulation Study Group and the International ARM Epidemiological Study Group. Results: The concordance of age-related macular degeneration was 90% in monozygotic twin pairs which significantly exceeded that of twin/spouse pairs (70.2%); p = 0.0279. In the nine pairs that were concordant, fundus appearance and visual impairment were similar. Environmental factors and medical history were essentially the same in the twin pairs. Couclusion: The statistically significant higher concordance of age-related macular degeneration in monozygotic twins compared to their spouses strongly suggests the importance of genetic factors.

Original languageEnglish
Pages (from-to)422-425
Number of pages4
JournalActa Ophthalmologica Scandinavica
Volume77
Issue number4
DOIs
Publication statusPublished - Aug 1999

Other keywords

  • Age-related macular degeneration
  • Atrophy
  • Concordance
  • Drusen
  • Macula
  • Monozygotic

Fingerprint

Dive into the research topics of 'Age related macular degeneration in monozygotic twins and their spouses in Iceland'. Together they form a unique fingerprint.

Cite this