Acute uveitic phase of Vogt-Koyanagi-Harada disease: optic nerve head swelling, ocular blood flow and retinal oxygen metabolism

Ahmed M. Abu El-Asrar*, Abdulrahman F. AlBloushi, Priscilla W. Gikandi, Abdullah Alzubaidi, Einar Stefánsson

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

Abstract

Objectives: To investigate the association of optic nerve head (ONH) swelling in the acute uveitic phase of Vogt-Koyanagi-Harada (VKH) disease with blood flow velocity in the choroid and ONH and oxygen saturation and diameter of retinal vessels. Methods: In this prospective study, 25 patients (50 eyes) were studied. Thirteen patients (26 eyes) had ONH swelling and 12 patients (24 eyes) had no ONH swelling. Laser speckle flowgraphy (LSFG) and retinal oximetry measurements were performed at presentation. Results: In the ONH, mean blur rate (MBR)-vessel, representing blood flow velocity in retinal vessels, was significantly lower in the eyes affected by ONH swelling, while choroidal MBR was not significantly different. Eyes with ONH swelling had a significantly lower oxygen saturation in retinal venules, a significantly higher arteriovenous oxygen saturation difference and a significantly smaller calibre of retinal arterioles compared with eyes without ONH swelling. There were significant positive correlations between the MBR-vessel of the ONH and venular oxygen saturation and calibre of retinal arterioles. In addition, MBR-vessel of the ONH had a significant negative correlation with arteriovenous oxygen saturation difference. Conclusions: The occurrence of ONH swelling in the acute uveitic phase of VKH disease is associated with lower retinal blood flow velocity and smaller calibre of retinal arterioles as well as lower oxygen saturation in retinal venules and higher arteriovenous difference in oxygen saturation.

Original languageEnglish
Pages (from-to)1432-1438
Number of pages7
JournalEye (Basingstoke)
Volume37
Issue number7
DOIs
Publication statusPublished - 29 Jun 2022

Bibliographical note

Funding Information:
This work was supported by King Saud University through Vice Deanship of Research Chair, Dr. Nasser Al Rashid Research Chair in Ophthalmology (AMA).

Publisher Copyright:
© 2022, The Author(s), under exclusive licence to The Royal College of Ophthalmologists.

Other keywords

  • Humans
  • Uveomeningoencephalitic Syndrome
  • Optic Disk/blood supply
  • Oxygen
  • Prospective Studies
  • Uveitis
  • Blood Flow Velocity/physiology
  • Papilledema
  • Regional Blood Flow/physiology

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