A susceptibility gene for psoriatic arthritis maps to chromosome 16q: evidence for imprinting

Ari Karason, Johann E Gudjonsson, Ruchi Upmanyu, Arna A Antonsdottir, Valdimar B Hauksson, E Hjaltey Runasdottir, Hjortur H Jonsson, Daniel F Gudbjartsson, Michael L Frigge, Augustine Kong, Kari Stefansson, Helgi Valdimarsson, Jeffrey R Gulcher

Research output: Contribution to journalArticlepeer-review


Several genetic loci have been reported for psoriasis, but none has been specifically linked to psoriatic arthritis (PsA), a condition that affects >10% of patients with psoriasis. A genetic component for PsA is suggested by segregation within families and high concordance among identical twins. We performed a linkage scan to map genes contributing to PsA. We identified 178 patients with PsA out of 906 patients who were included in our genetic study of psoriasis. Using a comprehensive genealogy database, we were able to connect 100 of these into 39 families. We genotyped the patients using a framework marker set of 1,000 microsatellite markers, with an average density of 3 cM, and performed multipoint, affected-only, allele-sharing linkage analysis using the Allegro program. On the basis of the initial results, we genotyped more markers for the most prominent loci. A linkage with a LOD score of 2.17 was observed on chromosome 16q. The linkage analysis, conditioned on paternal transmission to affected individuals, gave a LOD score of 4.19, whereas a LOD score of only 1.03 was observed when conditioned for maternal transmission. A suggestive locus on chromosome 16q has previously been implicated in psoriasis. Our data indicate that a gene at this locus may be involved in paternal transmission of PsA.
Original languageEnglish
JournalAmerican Journal of Human Genetics
Publication statusPublished - 1 Jan 2003

Other keywords

  • Alleles
  • Arthritis, Psoriatic
  • Chromosome Mapping
  • Chromosomes, Human, Pair 16
  • Female
  • Genetic Predisposition to Disease
  • Genomic Imprinting
  • Humans
  • Lod Score
  • Male
  • Microsatellite Repeats


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