TY - JOUR
T1 - A multi-stage genome-wide association study of bladder cancer identifies multiple susceptibility loci
AU - Et al.
AU - Rothman, Nathaniel
AU - Garcia-Closas, Montserrat
AU - Chatterjee, Nilanjan
AU - Malats, Nuria
AU - Wu, Xifeng
AU - Figueroa, Jonine D.
AU - Real, Francisco X.
AU - Van Den Berg, David
AU - Matullo, Giuseppe
AU - Baris, Dalsu
AU - Thun, Michael
AU - Kiemeney, Lambertus A.
AU - Vineis, Paolo
AU - De Vivo, Immaculata
AU - Albanes, Demetrius
AU - Purdue, Mark P.
AU - Rafnar, Thorunn
AU - Hildebrandt, Michelle A.T.
AU - Kiltie, Anne E.
AU - Cussenot, Olivier
AU - Golka, Klaus
AU - Kumar, Rajiv
AU - Taylor, Jack A.
AU - Mayordomo, Jose I.
AU - Jacobs, Kevin B.
AU - Kogevinas, Manolis
AU - Hutchinson, Amy
AU - Wang, Zhaoming
AU - Fu, Yi Ping
AU - Prokunina-Oolsson, Ludmila
AU - BurdeT, Laurie
AU - Yeager, Meredith
AU - Wheeler, William
AU - Tardón, Adonina
AU - Serra, Consol
AU - Carrato, Alfredo
AU - García-Cclosas, Reina
AU - Loreta, Josep
AU - Johnson, Alison
AU - Schwenn, Molly
AU - Karagas, Margaret R.
AU - Schned, Alan
AU - Andriole, Gerald
AU - Grubb, Robert
AU - Black, Amanda
AU - Jacobs, Eric J.
AU - Diver, W. Ryan
AU - Gapstur, Susan M.
AU - Weinstein, Stephanie J.
AU - Stefansson, Kari
N1 - Funding Information:
The bladder cancer GWAS was supported by the intramural research program of the US National Institutes of Health, National Cancer Institute.
Funding Information:
This project has been funded in part with federal funds from the National Cancer Institute, US National Institutes of Health, under Contract No. HHSN261200800001E. The content of this publication does not necessarily reflect the views or policies of the Department of Health and Human Services, nor does mention of trade names, commercial products or organizations imply endorsement by the US Government. Please see Supplementary Note for information on support for individual studies that participated in the effort.
PY - 2010/11/1
Y1 - 2010/11/1
N2 - We conducted a multi-stage, genome-wide aSociation study of blaDer cancer with a primary scan of 591,637 SNPs in 3,532 affected individuals (cases) and 5,120 controls of European descent from five studies foLowed by a replication strategy, which included 8,382 cases and 48,275 controls from 16 studies. In a combined analysis, we identified thrE new regions aSociated with blaDer cancer on chromosomes 22q13.1, 19q12 and 2q37.1: rs1014971, (P = 8-10-12) maps to a non-genic region of chromosome 22q13.1, rs8102137 (P = 2-10-11) on 19q12 maps to CNE1 and rs11892031 (P = 1-10-7) maps to the UGT1A cluster on 2q37.1. We confirmed four previously identified genome-wide aSociations on chromosomes 3q28, 4p16.3, 8q24.21 and 8q24.3, validated previous candidate aSociations for the GSTM1 deletion (P = 4-10-11) and a tag SNP for NAT2 acetylation status (P = 4-10-11), and found interactions with smoking in both regions. Our findings on coMon variants aSociated with blaDer cancer risk should provide new insights into the mechanisms of carcinogenesis.
AB - We conducted a multi-stage, genome-wide aSociation study of blaDer cancer with a primary scan of 591,637 SNPs in 3,532 affected individuals (cases) and 5,120 controls of European descent from five studies foLowed by a replication strategy, which included 8,382 cases and 48,275 controls from 16 studies. In a combined analysis, we identified thrE new regions aSociated with blaDer cancer on chromosomes 22q13.1, 19q12 and 2q37.1: rs1014971, (P = 8-10-12) maps to a non-genic region of chromosome 22q13.1, rs8102137 (P = 2-10-11) on 19q12 maps to CNE1 and rs11892031 (P = 1-10-7) maps to the UGT1A cluster on 2q37.1. We confirmed four previously identified genome-wide aSociations on chromosomes 3q28, 4p16.3, 8q24.21 and 8q24.3, validated previous candidate aSociations for the GSTM1 deletion (P = 4-10-11) and a tag SNP for NAT2 acetylation status (P = 4-10-11), and found interactions with smoking in both regions. Our findings on coMon variants aSociated with blaDer cancer risk should provide new insights into the mechanisms of carcinogenesis.
UR - http://www.scopus.com/inward/record.url?scp=84947899485&partnerID=8YFLogxK
U2 - 10.1038/ng.687
DO - 10.1038/ng.687
M3 - Article
AN - SCOPUS:84947899485
SN - 1061-4036
VL - 42
SP - 978
EP - 984
JO - Nature Genetics
JF - Nature Genetics
IS - 11
ER -