A genome-scale, constraint-based approach to systems biology of human metabolism

Monica L. Mo, Neema Jamshidi, Bernhard Palsson*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

45 Citations (Scopus)


The recent sequencing and annotation of the human genome enables a new era in biomedicine that will be based on an interdisciplinary, systemic approach to the elucidation and treatment of human disease. Reconstruction of genome-scale metabolic networks is an important part of this approach since networks represent the integration of diverse biological data such as genome annotations, high-throughput data, and legacy biochemical knowledge. This article will describe Homo sapiens Recon 1, a functionally tested, genome-scale reconstruction of human cellular metabolism, and its capabilities for facilitating the understanding of physiological and disease metabolic states.

Original languageEnglish
Pages (from-to)598-603
Number of pages6
JournalMolecular BioSystems
Issue number9
Publication statusPublished - 2007


Dive into the research topics of 'A genome-scale, constraint-based approach to systems biology of human metabolism'. Together they form a unique fingerprint.

Cite this