TY - JOUR
T1 - A comprehensive model of human erythrocyte metabolism
T2 - Extensions to include pH effects
AU - Lee, I. D.
AU - Palsson, B. O.
PY - 1990
Y1 - 1990
N2 - A mathematical model of the human erythrocyte, which accounts both for the metabolism of the cell and its interactions with the environment, has been constructed. The pH-dependence of enzyme activities is added to a previous model, which accounts for glycolysis, pentose phosphate pathway, nucleotide synthesis, membrane transport, osmotic balance, and conditions of electroneutrality. The extended model predicts well the dynamic behavior of the red cell in response to glucose depletion and pH variation.
AB - A mathematical model of the human erythrocyte, which accounts both for the metabolism of the cell and its interactions with the environment, has been constructed. The pH-dependence of enzyme activities is added to a previous model, which accounts for glycolysis, pentose phosphate pathway, nucleotide synthesis, membrane transport, osmotic balance, and conditions of electroneutrality. The extended model predicts well the dynamic behavior of the red cell in response to glucose depletion and pH variation.
UR - http://www.scopus.com/inward/record.url?scp=0025687613&partnerID=8YFLogxK
M3 - Article
C2 - 2082921
AN - SCOPUS:0025687613
SN - 0232-766X
VL - 49
SP - 771
EP - 789
JO - Biomedica Biochimica Acta
JF - Biomedica Biochimica Acta
IS - 8-9
ER -