A clinical score predicting a brief and uneventful course of newly diagnosed idiopathic thrombocytopenic purpura in children.

Pernille Wendtland Edslev, Steen Rosthøj, Iris Treutiger, Jukka Rajantie, Bernward Zeller, Olafur G Jonsson

Research output: Contribution to journalArticlepeer-review

Abstract

The Nordic idiopathic thrombocytopenic purpura study data showed that morbidity occurred mainly in children with thrombocytopenia lasting >3 months, whereas, the risk period with platelet counts <20 x 10(9)/l was short and the number of bleeding events low in children with shorter disease duration. These brief, uneventful courses were predicted by developing a scoring system based on six clinical features: abrupt onset (weight 5), age <10 years (3), preceding infection (2), platelet count <5 x 10(9)/l, wet purpura (1) and male gender (1). The score was derived and validated in two different cohorts of children. High scores (10-14) clearly identified low-risk patients. The score provides valid prognostic information and may be useful in clinical decision-making.
Original languageEnglish
JournalBritish Journal of Haematology
DOIs
Publication statusPublished - 1 Aug 2007

Other keywords

  • Age Factors
  • Child
  • Female
  • Health Status Indicators
  • Humans
  • Immunoglobulins, Intravenous
  • Male
  • Odds Ratio
  • Platelet Count
  • Prognosis
  • Prospective Studies
  • Purpura, Thrombocytopenic, Idiopathic
  • Risk Assessment
  • Sex Factors

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