TY - JOUR
T1 - A Breast Cancer Candidate Locus at 6q Narrowed to 6q15-q21
AU - Csuka, Dorottya
AU - Freysteinsdóttir, Edda Sigríður
AU - Jóhannesdóttir, Guðrún
AU - Agnarsson, Bjarni Agnar
AU - Jóhannsson, Óskar Þór
AU - Barkardóttir, Rósa Björk
AU - Arason, Aðalgeir
N1 - Publisher Copyright:
© 2024 by the authors.
PY - 2024/2/8
Y1 - 2024/2/8
N2 - Although a number of high-risk breast cancer genes have been identified, including BRCA1 and BRCA2, the risk profile of many high-risk families cannot be explained using known breast cancer genes. Previously, we have shown strong indications of new breast cancer risk loci at chromosomes 2p, 6q, and 14q in a family of six generations including 10 breast cancer cases. In this study, we identified and traced four new family branches descending from siblings of the parents in the top generation of the studied family. One distantly related branch included four breast cancer cases, two of whom were diagnosed at age < 45 years. DNA samples from the cases were typed at selected polymorphic markers from all three chromosome loci, to test identical origin of the haplotypes. All four cases were shown to segregate a common 6q haplotype with a region identical to the previously identified 6q haplotype. The data strongly support a new breast cancer locus at 6q, and narrow it down to a 17 MB interval at 6q15-q21.
AB - Although a number of high-risk breast cancer genes have been identified, including BRCA1 and BRCA2, the risk profile of many high-risk families cannot be explained using known breast cancer genes. Previously, we have shown strong indications of new breast cancer risk loci at chromosomes 2p, 6q, and 14q in a family of six generations including 10 breast cancer cases. In this study, we identified and traced four new family branches descending from siblings of the parents in the top generation of the studied family. One distantly related branch included four breast cancer cases, two of whom were diagnosed at age < 45 years. DNA samples from the cases were typed at selected polymorphic markers from all three chromosome loci, to test identical origin of the haplotypes. All four cases were shown to segregate a common 6q haplotype with a region identical to the previously identified 6q haplotype. The data strongly support a new breast cancer locus at 6q, and narrow it down to a 17 MB interval at 6q15-q21.
KW - hereditary breast cancer
KW - non-BRCA1/2
KW - oligogenic cancer susceptibility
UR - http://www.scopus.com/inward/record.url?scp=85185899002&partnerID=8YFLogxK
U2 - 10.3390/genes15020218
DO - 10.3390/genes15020218
M3 - Article
C2 - 38397208
SN - 2073-4425
VL - 15
JO - Genes
JF - Genes
IS - 2
M1 - 218
ER -
