Genetics and Molecular Biology of Breast Cancer

Ingvarsson, S. (Participant)

Activity: Participating in or organising an event › Organising a conference, workshop, ...

Period	2 Sept 1992 → 6 Sept 1992
Event type	Conference
Location	Cold Spring Harbor, United StatesShow on map
Degree of Recognition	International

Documents & Links

CSH1992Abstracts
File: application/pdf, 5.38 MB
Type: Text
Ingvarsson1992CSH
File: application/pdf, 391 KB
Type: Text

https://www.osti.gov/servlets/purl/10190599
The short arm of chromosome 3 is frequently affected by cytogenetic changes associated with human malignancies. We have found loss of heterozygosity (LOH) in sporadic renal cell carcinoma (RCC) and breast carcinoma, in 84% and 29% of cases, respectively, lt remains unknown whether the disorders reside in lesions of the same gene. Thus, the data strongly support the presence of at least one powerful tumor suppressor gene in the 3p region. The 3p loss in breast carcinoma seems to correlate with higher degree of malignancy. Since these tumor types are seen both in mouse and rat it appeared important to localize the mouse and rat homologues on the chromosome map. Our findings showed that both are localized in regions previously shown to be syntenic with human chromosome 3, chromosome 9 in mouse and chromosome 8 in rat. We are doing linkage studies on families in Iceland showing high rate of breast cancer. Some of the family members develop also other tumor types, known to carry a 3p abnormality, suggesting 3p as possible site for breast cancer susceptibility locus. Blood samples from 105 persons (affected and relatives) from 8 breast cancer families have been collected for an initial screening concerning 5 loci on chromosome 3p. Linkage to 3p has been excluded in 4 breast cancer families and multipoint analysis is under way for the remaining families.
https://library.ncifrederick.cancer.gov/discovery/fulldisplay?docid=alma991000047819706426&context=L&vid=01FREDERICK_INST:01FREDERICK&lang=en&search_scope=MyInst_and_CI&adaptor=Local%20Search%20Engine&tab=Everything&query=creator,exact,Cold%20Spring%20Harbor%20Meeting%20on%20Cancer%20Cells&facet=creator,exact,Cold%20Spring%20Harbor%20Meeting%20on%20Cancer%20Cells&offset=10
https://search.library.ucsf.edu/discovery/fulldisplay?docid=alma991001098649706536&context=L&vid=01UCS_SAF:UCSF&lang=en&search_scope=DN_and_CI&adaptor=Local%20Search%20Engine&tab=Everything&query=mesh,exact,Growth%20Substances%20--%20physiology,AND&mode=advanced&offset=0
https://search.library.wisc.edu/search/system/author?q=%22Cold+Spring+Harbor+Meeting+on+Cancer+Cells+%281992%29%22
https://www.osti.gov/biblio/10190599